Gimeracil Chemical Properties

Melting point:

274 °C

Boiling point:

255.1±40.0 °C(Predicted)

Density 

1.56±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

Soluble in DMSO (up to 5 mg/ml).

pka

4.50±1.00(Predicted)

form 

solid

color 

White

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

InChIKey

ZPLQIPFOCGIIHV-UHFFFAOYSA-N

CAS DataBase Reference

103766-25-2(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

HS Code 

29337900

Gimeracil Usage And Synthesis

Description

Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2? Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3

Chemical Properties

Off-White Solid

Uses

Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.

Uses

Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).

Uses

Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD)

Definition

ChEBI: Gimeracil is an organic molecular entity.

References

1) Diasio (1999)?Clinical implications of dihydropyrimidine dehydrogenase inhibition; Oncology(Williston Park),?13?17 2) Kobayakawa and Kojima (2011),?Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies; Onco. Targets Ther.,?4?193 3) Sakata?et al.?(2011),?Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination; Cancer Sci.,?102?1712

Gimeracil(103766-25-2)Related Product Information

• 2,4-Dihydroxypyridine
• 2-Chloro-5-chloromethylpyridine
• Clopidol
• 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE
• 5-Chloropyridine-2,3-diol
• 2,4-Dihydroxypyridine
• Gimeracil-13C3
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