Basic information Safety Supplier Related

27-DEOXYACTEIN

Basic information Safety Supplier Related

27-DEOXYACTEIN Basic information

Product Name:
27-DEOXYACTEIN
Synonyms:
  • 23-EPI-26-Deoxyactein (20 mg)
  • DEOXYACTEIN, 27-(23-EPI-26-DEOXYACTEIN)(P)
  • (3beta,12beta,16beta,23S,24R,25R)-12-(Acetyloxy)-16,23:23,26:24,25-triepoxy-9,19-cyclolanostan-3-yl beta-D-xylopyranoside
  • DEOXYACTEIN, 27-
  • 23-EPI-26-DEOXYACTEIN
  • 26-DEOXYACTEIN
  • 27-DEOXYACTEIN
  • β-D-Xylopyranoside, (3β,12β,16β,23S,24R,25R)-12-(acetyloxy)-16,23:23,26:24,25-triepoxy-9,19-cyclolanostan-3-yl
CAS:
264624-38-6
MF:
C37H56O10
MW:
660.83
Mol File:
264624-38-6.mol
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27-DEOXYACTEIN Chemical Properties

Melting point:
253~254℃
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), Methanol (Very Slightly), Pyridine (Slightly)
form 
Solid
pka
13.03±0.70(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
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27-DEOXYACTEIN Usage And Synthesis

Description

23-epi-26-Deoxyactein is a triterpene glycoside and a major constituent of black cohosh (C. racemosa). It reduces intracellular calcium concentrations, collapse of the mitochondrial membrane potential, production of reactive oxygen species (ROS), and cardiolipin peroxidation and inhibits autophagy and apoptosis in osteoblastic MC3T3-E1 cells induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). 23-epi-26-Deoxyactein (0.01-10 μM) reduces production of ROS and IL-1β and cell death induced by methylglyoxal in RIN-m5F β-cells.

Uses

27-Deoxyactein has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of Actein (A191800), a gamma secretase modulators derived from botanicals.

Definition

ChEBI: 26-Deoxyactein is a triterpenoid. It has a role as a metabolite.

27-DEOXYACTEINSupplier

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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Sinopharm Chemical Reagent Co,Ltd.
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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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Shanghai T&W Pharmaceutical Co., Ltd.
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Shanghai Tauto Biotech Co., Ltd.
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021-51320588
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tauto@tautobiotech.com