27-DEOXYACTEIN
27-DEOXYACTEIN Basic information
- Product Name:
- 27-DEOXYACTEIN
- Synonyms:
-
- 23-EPI-26-Deoxyactein (20 mg)
- DEOXYACTEIN, 27-(23-EPI-26-DEOXYACTEIN)(P)
- (3beta,12beta,16beta,23S,24R,25R)-12-(Acetyloxy)-16,23:23,26:24,25-triepoxy-9,19-cyclolanostan-3-yl beta-D-xylopyranoside
- DEOXYACTEIN, 27-
- 23-EPI-26-DEOXYACTEIN
- 26-DEOXYACTEIN
- 27-DEOXYACTEIN
- β-D-Xylopyranoside, (3β,12β,16β,23S,24R,25R)-12-(acetyloxy)-16,23:23,26:24,25-triepoxy-9,19-cyclolanostan-3-yl
- CAS:
- 264624-38-6
- MF:
- C37H56O10
- MW:
- 660.83
- Mol File:
- 264624-38-6.mol
27-DEOXYACTEIN Chemical Properties
- Melting point:
- 253～254℃
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Methanol (Very Slightly), Pyridine (Slightly)
- form
- Solid
- pka
- 13.03±0.70(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
27-DEOXYACTEIN Usage And Synthesis
Description
23-epi-26-Deoxyactein is a triterpene glycoside and a major constituent of black cohosh (C. racemosa). It reduces intracellular calcium concentrations, collapse of the mitochondrial membrane potential, production of reactive oxygen species (ROS), and cardiolipin peroxidation and inhibits autophagy and apoptosis in osteoblastic MC3T3-E1 cells induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). 23-epi-26-Deoxyactein (0.01-10 μM) reduces production of ROS and IL-1β and cell death induced by methylglyoxal in RIN-m5F β-cells.
Uses
27-Deoxyactein has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of Actein (A191800), a gamma secretase modulators derived from botanicals.
Definition
ChEBI: 26-Deoxyactein is a triterpenoid. It has a role as a metabolite.
References
[1] KWANG SIK SUH. 27-Deoxyactein prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cellular damage in MC3T3-E1 osteoblastic cells.[J]. Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering, 2018, 53 6: 561-570. DOI: 10.1080/10934529.2018.1428275
[2] KWANG SIK SUH. Deoxyactein protects pancreatic β-cells against methylglyoxal-induced oxidative cell damage by the upregulation of mitochondrial biogenesis.[J]. International journal of molecular medicine, 2017, 40 2: 539-548. DOI: 10.3892/ijmm.2017.3018
27-DEOXYACTEINSupplier
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- 18210857532; 18210857532
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27-DEOXYACTEIN(264624-38-6)Related Product Information
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