4-isopropylcyclohexanol Chemical Properties

Melting point:

36.9°C (estimate)

Boiling point:

110°C/22mmHg(lit.)

Density 

0.9103 (estimate)

vapor pressure 

4.73-6.3Pa at 20-25℃

refractive index 

gt. 1.4660 to 1.4700

Flash point:

95 °C

storage temp. 

Sealed in dry,Room Temperature

solubility 

Almost insoluble in water, soluble in alcohol and oils

form 

clear liquid

pka

15.30±0.40(Predicted)

color 

Colorless to Almost colorless

Odor

at 10.00 % in dipropylene glycol. leather red rose green dusty weedy metallic

Odor Type

leathery

LogP

2.7-2.8 at 35℃

Surface tension

36.7mN/m at 1g/L and 20℃

EPA Substance Registry System

Cyclohexanol, 4-(1-methylethyl)- (4621-04-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

41

Safety Statements 

26-39

RTECS 

GV9620000

HS Code 

2906190090

4-isopropylcyclohexanol Usage And Synthesis

Uses

4-isopropylcyclohexanol has been suggested for use in perfume compositions on account of its power, low cost, and stability in soap. It has acceptable effects upon Lavender, Pine and even on Rose type fragrances for such purpose, but it needs proper blending with sweetening materials of similar volatility, e.g. Linalool, Phenylethyl alcohol, Anethole, Citronellol, esters, etc. It blends well with the conventional Fougère materials and with many of the newer Cyclohexane derivatives.

Preparation

1) by hydrogenation of para-iso-Propyl phenol.
2) by electrolytic reduction of Cryptone, which can be obtained as an isolate from Eucalyptus oil fractions or certain Pine needle oils.

Biochem/physiol Actions

4-isopropylcyclohexanol (4-iPr-CyH-OH), a novel analgesic compound ,  which inhibited TRPV1, TRPA1, TRPM8, TRPV4 and ANO1, as well as mitigated capsaicin-induced pain-related behaviors in mice. Moreover, the absence of an agonist effect for 4-iPr-CyH-OH on these five channels may reduce side effects and dosages[1].

References

[1] Yasunori Takayama, M. Tominaga, H. Furue. “4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities.” Scientific Reports (2017).

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