Basic information Safety Supplier Related

DIBENZEPINE HCL

Basic information Safety Supplier Related

DIBENZEPINE HCL Basic information

Product Name:
DIBENZEPINE HCL
Synonyms:
  • )diazepin
  • 5-methyl-10-beta-dimethylaminoaethyl-10,11-dihydro-11-oxo-5-dibenzo(b,e)(1,4
  • dibenzepinehydrochloride
  • dibenzepinhydrochloride
  • ecatril
  • hydrofluoride-1927wander
  • neodalit
  • noveril
CAS:
315-80-0
MF:
C18H22ClN3O
MW:
331.84
EINECS:
206-255-6
Product Categories:
  • Inhibitors
Mol File:
315-80-0.mol
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DIBENZEPINE HCL Chemical Properties

Melting point:
238°
pka
8.25(at 25℃)
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Safety Information

RIDADR 
3249
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 orally in mice: 215 mg/kg (Hunziker)
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DIBENZEPINE HCL Usage And Synthesis

Originator

Noveril ,Wander,Switz.,1965

Uses

Antidepressant.

Definition

ChEBI: Dibenzepin hydrochloride is a dibenzodiazepine.

Manufacturing Process

4.48 grams of 5-methyl-11-hydroxy-5H-dibenzo[b,e][1,4]diazepine and 0.86
gram of sodium amide were boiled for one hour in 50 ml of absolute dioxane. After adding a concentrated benzenic solution of β-dimethylamino-ethyl chloride freshly prepared from 3.75 grams of the hydrochloride with concentrated sodium hydroxide solution, taking up in benzene and drying the solution with potash, the mixture was boiled for 16 hours under reflux, whereupon the reaction mixture was concentrated to dryness and the residue distributed between ether and water. By exhaustive extraction of the basic fractions with dilute acetic acid, precipitation with ammonia, taking up the base in ether and working up the ethereal solution, there was obtained 5.05 grams (85% of the theoretical) of 5-methyl-10-β-dimethylamino-ethyl-10,11- dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine in the form of a viscous yellowish resin with the boiling point 185°C/0.01mm Hg. The base was crystallized from acetone-petroleum ether, MP 116°-117°C. Melting point of the monohydrochloride (from ethanol-ether) 234°-240°C.

brand name

Deprex;Ecatrol;Hf 1927;Neodit;Victoril.

Therapeutic Function

Psychostimulant

World Health Organization (WHO)

Dibenzepin hydrochloride, a tricyclic antidepressant, was introduced in 1968 for the treatment of depressive illness. By 1973 its use in Sweden had been associated with an unexpectedly high number of suicide attempts which led to its withdrawal in that country. Although its use has lapsed in several countries, it remains available in at least eight European countries.

DIBENZEPINE HCLSupplier

Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
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isunpharm@qq.com
GIHI CHEMICALS CO.,LTD
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0086-571-86217390
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Sales@gihichem.com
Target molecule Corp.
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857-239-0968
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Shanghai hongqu biomedical technology co. LTD
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88888888888
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hongquchem@qq.com
Energy Chemical
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021-58432009 400-005-6266
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marketing@energy-chemical.com