(4E)-TCO-PEG4-biotin Chemical Properties

Boiling point:

837.0±65.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

11.95±0.46(Predicted)

(4E)-TCO-PEG4-biotin Usage And Synthesis

Description

TCO-PEG4-biotin is a biotinylation reagent containing TCO moieties. TCO enable click chemistry with tetrazine. The hydrophilic PEG spacer improves the water solubility of compounds.

Uses

TCO-PEG4-biotin is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001

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