ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > 1-ISOPROPYL-PIPERIDIN-4-YLAMINE
1-ISOPROPYL-PIPERIDIN-4-YLAMINE
1-ISOPROPYL-PIPERIDIN-4-YLAMINE Basic information
- Product Name:
- 1-ISOPROPYL-PIPERIDIN-4-YLAMINE
- Synonyms:
-
- 4-Piperidinamine, 1-(1-methylethyl)-
- 1-isopropylpiperidin-4-amine(SALTDATA: 1.98HCl 0.34H2O)
- 1-isopropylpiperidin-4-amine 1.98HCl 0.34H2O
- 1-(propan-2-yl)piperidin-4-aMine
- (1-isopropyl-4-piperidyl)amine
- 1-(Prop-2-yl)piperidin-4-amine, 1-Isopropylpiperidin-4-amine
- 1-Isopropyl-4-PiperidinaMine
- 1-ISOPROPYLPIPERIDIN-4-AMINE
- CAS:
- 127285-08-9
- MF:
- C8H18N2
- MW:
- 142.24
- Product Categories:
-
- Heterocycles
- Mol File:
- 127285-08-9.mol
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1-ISOPROPYL-PIPERIDIN-4-YLAMINE Chemical Properties
- Boiling point:
- 173.2±8.0 °C(Predicted)
- Density
- 0.904±0.06 g/cm3(Predicted)
- refractive index
- 1.4720 to 1.4760
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- clear liquid
- pka
- 10.51±0.20(Predicted)
- color
- Colorless to Almost colorless
- InChI
- InChI=1S/C8H18N2/c1-7(2)10-5-3-8(9)4-6-10/h7-8H,3-6,9H2,1-2H3
- InChIKey
- ZRQQXFMGYSOKDF-UHFFFAOYSA-N
- SMILES
- N1(C(C)C)CCC(N)CC1
- CAS DataBase Reference
- 127285-08-9(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-36-22
- Safety Statements
- 26-36/37/39
- RIDADR
- UN 2920 8/3/PG II
- HazardClass
- IRRITANT
- PackingGroup
- II
- HS Code
- 2933399990
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1-ISOPROPYL-PIPERIDIN-4-YLAMINE Usage And Synthesis
Uses
1-Isopropylpiperidin-4-amine is used as a pharmaceutical intermediate compound for the preparation of antiviral compounds or small molecule bioactive inhibitors.
Synthesis
609804-23-1
127285-08-9
GENERAL METHOD: Compound I-5 (240 mg) was dissolved in hexafluoroisopropanol (HFIP, 8 mL) and 10% palladium/carbon (Pd/C, 120 mg) was added. The reaction mixture was stirred at room temperature for 20 h under hydrogen atmosphere (1 atm). Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to give the yellow oily product I-6 (100 mg, 75% yield).
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 132, p. 26 - 41
[2] Patent: EP1489078, 2004, A1. Location in patent: Page 130
1-ISOPROPYL-PIPERIDIN-4-YLAMINESupplier
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