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N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

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N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Basic information

Product Name:
N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
Synonyms:
  • N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
  • LORCAINIDE HYDROCHLORIDE
  • Isocainide hydrochloride
  • 4'-Chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide monohydrochloride
  • Benzeneacetamide, N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]-, monohydrochloride
  • Nsc310411
  • N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride USP/EP/BP
  • Lorcainide HCl
CAS:
58934-46-6
MF:
C22H28Cl2N2O
MW:
407.37652
EINECS:
261-504-6
Mol File:
58934-46-6.mol
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N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Chemical Properties

Melting point:
263°
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 20 mg/ml), in Water (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml).
form 
White solid.
color 
Powder
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 1 month
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N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Usage And Synthesis

Description

Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+?channel blocker.1?Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2?Acts at the ouabain binding site of guinea pig cardiac Na+/K+?ATPase and inhibits the enzyme (IC50?= 34 μM).3

Uses

Cardiac depressant (anti-arrhythmic).

References

1) Sheldon?et al.?(1989),?Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem.,?35?748 2) Lynch?et al.?(1995),?Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther.,?273?554 3) Almotrefi?et al. (1999),?Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol.,?77?866

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