N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Chemical Properties

Melting point:

263°

storage temp. 

-20°C

solubility 

Soluble in DMSO (up to 20 mg/ml), in Water (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml).

form 

White solid.

color 

Powder

Water Solubility 

H2O: 10mg/mL, clear

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 1 month

N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Usage And Synthesis

Description

Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+?channel blocker.1?Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2?Acts at the ouabain binding site of guinea pig cardiac Na+/K+?ATPase and inhibits the enzyme (IC50?= 34 μM).3

Uses

Cardiac depressant (anti-arrhythmic).

References

[1] R S SHELDON  H J D  R J Hill. Antiarrhythmic drugs and the cardiac sodium channel: current models.[J]. Clinical chemistry, 1989, 35 5: 748-754.
[2] J J LYNCH. Sodium channel blockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists.[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 273 1: 554-560.
[3] A. ALMOTREFI. Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase.[J]. Canadian journal of physiology and pharmacology, 1999, 77 11 1: 866-870. DOI:10.1139/y99-091

N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride(58934-46-6)Related Product Information

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