4-ACETAMIDOPIPERIDINE Chemical Properties

Melting point:

141 °C

Boiling point:

318.5±31.0 °C(Predicted)

Density 

1.02

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

15.96±0.20(Predicted)

color 

White to Almost white

CAS DataBase Reference

5810-56-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

36/37/39-37-26

HS Code 

29333990

MSDS

• Language:English Provider:ALFA

4-ACETAMIDOPIPERIDINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 4-acetamido-piperidine from 4-acetamido-1-benzylpiperidine: preparation of intermediate 40: N-piperidin-4-yl-acetamide (method step 10). Pd-C (350 mg) was added to a solution of N-(1-benzyl-piperidin-4-yl)-acetamide (intermediate 39) (2.3 g, 10.0 mmol) in EtOH (35 mL) and HCl (1 M, 5 mL), and the mixture was stirred for 5 hr under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through diatomaceous earth followed by washing with EtOH and then water. The filtrate was concentrated under vacuum and the product was purified by column chromatography using a methanol solution of dichloromethane/7M NH3 (100:0 to 80:20) as eluent to give the intermediate 40 (0.92 g, 65% yield). Since the compound could not be detected by HPLC-MS, its structure was confirmed by NMR.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 14, p. 2303 - 2306
[2] Organic Process Research and Development, 2012, vol. 16, # 3, p. 470 - 483
[3] Patent: US2012/214798, 2012, A1
[4] Patent: US2005/43298, 2005, A1. Location in patent: Page/Page column 35
[5] Patent: US2005/197333, 2005, A1. Location in patent: Page/Page column 39-40

4-ACETAMIDOPIPERIDINE(5810-56-0)Related Product Information

• N-Phenyl-N-(4-piperidinyl)propanamide admixture with HCl salt
• Clebopride maleate
• Fentanyl citrate
• SUFENTANIL CITRATE
• 2,2,6,6-TETRAMETHYL-4-ACETAMIDOPIPERIDINE-1-OXYL
• 4-(2-BROMOACETAMIDO)-2,2,6,6-TETRAMETHYL-1-PIPERIDINYLOXY
• Mefentanyl
• N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
• 3-ACETAMIDOPIPERIDINE
• 4-ACETAMIDO-2,2,6,6-TETRAMETHYLPIPERIDINE
• 4-(2-IODOACETAMIDO)-TEMPO
• 4-MALEIMIDO-TEMPO
• 4-(2-CHLOROACETAMIDO)-2,2,6,6-TETRAMETHYLPIPERIDINE 1-OXYL
• ETHYL 4-ACETAMIDOPIPERIDINE-1-CARBOXYLATE
• azapride
• (8-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1-OXA-4,8-DIAZASPIRO[4.5]DEC-4-YL)(2-THIENYL)METHANONE
• (8-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1-OXA-4,8-DIAZASPIRO[4.5]DEC-4-YL)(4-NITROPHENYL)METHANONE
• (8-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1-OXA-4,8-DIAZASPIRO[4.5]DEC-4-YL)(PHENYL)METHANONE