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Chlorguanide Hydrochloride

Basic information Safety Supplier Related

Chlorguanide Hydrochloride Basic information

Product Name:
Chlorguanide Hydrochloride
Synonyms:
  • 1-(p-chlorophenyl)-5-isopropylbiguanidehydrochloride
  • N1-(4-Chlorophenyl)-N5-isopropylbiguanide Hydrochloride
  • 1-(p-chlorophenyl)-5-isopropyl-biguanidmonohydrochloride
  • 3359rp
  • chlorguanidehydrochloride
  • chloroguanidehydrochloride
  • chloroguanidinehydrochloride
  • diguanyl
CAS:
637-32-1
MF:
C11H17Cl2N5
MW:
290.19
EINECS:
211-283-7
Product Categories:
  • Aromatics
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • PALUDRINE
Mol File:
637-32-1.mol
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Chlorguanide Hydrochloride Chemical Properties

Melting point:
249-2510C
storage temp. 
2-8°C
solubility 
acetonitrile: water: ~1mg/mL (60/40)
form 
solid
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Safety Information

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
3249
WGK Germany 
3
RTECS 
DU1750000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2925294500
Toxicity
LD50 orally in rats: 200 mg/kg (Schmidt)
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Chlorguanide Hydrochloride Usage And Synthesis

Chemical Properties

White Solid

Uses

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

Uses

Chlorguanide Hydrochloride can be intended for use as an internal standard for the quantification of Proguanil by GC- or LC-mass spectrometry.

brand name

Paludrine (Zeneca).

General Description

Proguanil hydrochloride is a biguanide compound, widely used as an antimalarial drug. It exhibits sporontocidal activity, thereby rendering the gametocytes non-infective to the mosquito vector.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Chlorguanide HydrochlorideSupplier

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