Chlorguanide Hydrochloride
Chlorguanide Hydrochloride Basic information
- Product Name:
- Chlorguanide Hydrochloride
- Synonyms:
-
- 1-(p-chlorophenyl)-5-isopropylbiguanidehydrochloride
- N1-(4-Chlorophenyl)-N5-isopropylbiguanide Hydrochloride
- 1-(p-chlorophenyl)-5-isopropyl-biguanidmonohydrochloride
- 3359rp
- chlorguanidehydrochloride
- chloroguanidehydrochloride
- chloroguanidinehydrochloride
- diguanyl
- CAS:
- 637-32-1
- MF:
- C11H17Cl2N5
- MW:
- 290.19
- EINECS:
- 211-283-7
- Product Categories:
-
- Aromatics
- Bases & Related Reagents
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
- PALUDRINE
- Mol File:
- 637-32-1.mol
Chlorguanide Hydrochloride Chemical Properties
- Melting point:
- 249-2510C
- storage temp.
- 2-8°C
- solubility
- acetonitrile: water: ~1mg/mL (60/40)
- form
- solid
Chlorguanide Hydrochloride Usage And Synthesis
Chemical Properties
White Solid
Uses
Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.
Uses
Chlorguanide Hydrochloride can be intended for use as an internal standard for the quantification of Proguanil by GC- or LC-mass spectrometry.
brand name
Paludrine (Zeneca).
General Description
Proguanil hydrochloride is a biguanide compound, widely used as an antimalarial drug. It exhibits sporontocidal activity, thereby rendering the gametocytes non-infective to the mosquito vector.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biochem/physiol Actions
Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.
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Chlorguanide Hydrochloride(637-32-1)Related Product Information
- Proguanil Related Compound D (25 mg) (1,5-bis(1-methylethyl)biguanide hydrochloride)
- 1-(3-Chlorophenyl)-5-isopropylbiguanide Hydrochloride
- Proguanil Related Compound C (25 mg) (1,5-bis(4-chlorophenyl)biguanide hydrochloride)
- 1-Cyano-3-isopropylguanidine
- Levetiracetam
- Gemfibrozil
- GEMFIBROZIL RELATED COMPOUND A (20 MG) (2,2-DIMETHYL-5-[2,5-DIMETHYL-4-(PROPENE-1-YL)PHE-NOXY]VALERIC ACID)
- PROGUANIL HYDROCHLORIDE - REFERENCE SPECTRUM
- PROGUANIL HYDROCHLORIDE IMP. B (EP): 4-CHLOROANILINE
- GEMFIBROZIL IMPURITY A
- PROGUANIL HYDROCHLORIDE
- 1-(4-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE
- N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
- Chlorguanide Hydrochloride