Tricyclo[3.3.1.13,7]decane-1,3-diol, 5-amino- Chemical Properties

Melting point:

>246°C (dec.)

Boiling point:

316.3±37.0 °C(Predicted)

Density 

1.462±0.06 g/cm3(Predicted)

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

14.34±0.60(Predicted)

form 

Solid

color 

White to Off-White

Tricyclo[3.3.1.13,7]decane-1,3-diol, 5-amino- Usage And Synthesis

Uses

5-Aminotricyclo[3.3.1.13,7]decane-1,3-diol is an intermediate used in the synthesis of Hydroxy Vildagliptin (V305035), which is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-?4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.

Tricyclo[3.3.1.13,7]decane-1,3-diol, 5-amino-(1382839-19-1)Related Product Information

• 2-Pyrrolidinecarboxamide,1-(hydroxyacetyl)-,(S)-(9CI)
• (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile
• Vildagliptin Impurity ZA6
• 1,3,5,7-tetrahydroxyadamantane
• Amantadine
• Methyl L-prolinate hydrochloride
• Vildagliptin Impurity 19
• N-acetic acid-1-aMino-3-adaMantanol
• (R)-1-(2-chloroacetyl)pyrrolidine-2-carboxaMide
• Vildagliptin IMpurity 2 (Mixture of DiastereoMers)
• Vildagliptin Impurity 69
• vildagliptin Impurity Q
• Vildagliptin Related Compound F
• Vildagliptin Impurity 25
• (5aR,10aR)-1,2,3,5a,6,7,8,10a-octahydrodipyrrolo[1,2-c:1',2'-f]pyrazine-5,10-dione
• Dichloroacetyl chloride
• Vildagliptin Carboxylic Acid
• (5aS)-2,3,5aβ,6,7,8-Hexahydro-1H,5H-dipyrrolo[1,2-a:1',2'-d]pyrazine-5,10(10aβH)-dione