ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID CAS#: 148796-53-6

ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID Basic information

Product Name:

ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID

Synonyms:

HYDROXYFARNESYL PHOSPHATE
HFPA
(+/-)-1-HYDROXY-3,7,11-TRIMETHYL-2E,6E,10-DODECATRIENE-1-PHOSPHONIC ACID
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID
A-hydroxyfarnesylphosphonic acid
alpha-Hydroxyfarnesylphosphonic aicd
ALPHA-HYDROXYFARNESYL PHOSPHONIC ACID ETHANOL SOLUTION
MONZTFSZTWQCKH-IJFRVEDASA-N

CAS:

148796-53-6

MF:

C15H27O4P

MW:

302.35

EINECS:

200-578-6

Mol File:

148796-53-6.mol

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ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID Chemical Properties

storage temp.: −20°C
solubility: 10 mM Na2CO3: freely soluble; ETOH: >25 mg/ml; PBS pH 7.2: <25 μg/ml
form: A crystalline solid

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Safety Information

Hazard Codes: F,Xi
Risk Statements: 11-36/37/38
Safety Statements: 16-26-36-7
RIDADR: UN 1170 3/PG 2
WGK Germany: 3

MSDS

Language:English Provider:SigmaAldrich

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ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID Usage And Synthesis

Description

α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.

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