1,4-Dioxane-2,5-dione Chemical Properties

Melting point:

81-83°C

Boiling point:

130°C(lit.)

Density 

1.1315 (rough estimate)

refractive index 

1.4500 (estimate)

storage temp. 

-20°C

solubility 

Dichloromethane (Slightly), DMSO (Slightly)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

Cosmetics Ingredients Functions

HUMECTANT
SKIN CONDITIONING

InChI

InChI=1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2

InChIKey

RKDVKSZUMVYZHH-UHFFFAOYSA-N

SMILES

O1CC(=O)OCC1=O

CAS DataBase Reference

502-97-6(CAS DataBase Reference)

NIST Chemistry Reference

1,4-Dioxane-2,5-dione(502-97-6)

EPA Substance Registry System

1,4-Dioxane-2,5-dione (502-97-6)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-36-22

Safety Statements 

22-24/25-37/39-26

WGK Germany 

3

TSCA 

TSCA listed

HS Code 

29322090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2

MSDS

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1,4-Dioxane-2,5-dione Usage And Synthesis

Chemical Properties

mp 82-86°C 99.5+%

Uses

1,4-Dioxane-2,5-dione is used in the fabricating of artificial blood vessels.

General Description

Glycolide is a cyclic dimer of α-hydroxy acid that can be used in the formation of aliphatic polyester. It is synthesized by the dimerization of glycolic acid. It forms a low toxic synthetic biodegradable polymer that can be used in medical applications. It is majorly used in the formation of a highly crystalline poly(glycolide) by ring opening polymerization.

Flammability and Explosibility

Not classified

Synthesis

Weigh 50g of ethanoic acid into a 500ml double-necked flask, then add 0.05g of phenylalanine stannous catalyst (0.1wt%), pre-polymerization at atmospheric pressure, 120 ?? under the condition of 0.5h, and then increase the temperature to 160 ??, through the decompression distillation device for vacuum dewatering, the reaction of about 2h to no water discharge, you can get a white oligomer. Then 1,4-dioxane-2,5-hexanedione was collected by decompression cracking at 260??C. 5h was completed and 33.9g of crude 1,4-dioxane-2,5-hexanedione was received, the product yield was 89%, and the melting point of the product was 90.6??C.

1,4-Dioxane-2,5-dione(502-97-6)Related Product Information

• Selenium dioxide
• 2,5-Hexanedione
• 1,4-Dioxane
• MYRISTYL ACETATE
• Diethyl acetamidomalonate
• Quinoxaline-6-carboxylic acid ethyl ester
• 2-Morpholinecarboxylicacid,ethylester(9CI)
• Ethylene dimethacrylate
• 2,2,5-TRIMETHYL-1,3-DIOXANE-4,6-DIONE, 9 8%
• 2,3,5,6-tetramethyl-1,4-dioxane-2,5-diol
• 5-(1-Hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
• 2,2-Dimethyl-1,3-dioxane-4,6-dione
• 1,4-DIOXANE-2,5-DIOL,1,4-Dioxane-2,5-diol, 2,5-Dihydroxy-1,4-dioxane, Hydroxyacetaldehyde dimer
• (n)-3,6-dimethyl-1,4-dioxane-2,5-dione,DL-3,6-Dimethyl-1,4-dioxane-2,5-dione
• glycolide E-caprolactone copolymer
• 5-diazomeldrum'sacid(=5-diazo-2,2-dimethyl-1,3-dioxane-4,6-dione)
• Michler's ketone
• 2,5-Bis(hydroxymethyl)-1,4-dioxane-2,5-diol