THIOPHENE-2-THIOCARBOXAMIDE Chemical Properties

Melting point:

106 °C

Boiling point:

260℃

Density 

1.357

Flash point:

111℃

storage temp. 

2-8°C(protect from light)

form 

powder to crystal

pka

12.56±0.29(Predicted)

color 

White to Yellow to Green

Water Solubility 

Insoluble in water.

BRN 

110159

CAS DataBase Reference

20300-02-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

25-43

Safety Statements 

22-36/37/39-45-36/37

RIDADR 

2811

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

2934999090

MSDS

• Language:English Provider:ALFA

THIOPHENE-2-THIOCARBOXAMIDE Usage And Synthesis

Uses

Thiophene-2-thiocarboxamide is used as a pharmaceutical intermediate.

Synthesis

General procedure for the synthesis of thiophene-2-thioformamide from 2-thiophenecarboxamide: 2-thiophenecarboxamide (1 g, 7.86 mmol) was dissolved in dry 1,2-dimethoxyethane (30 mL). Lawesson's reagent (1.6 g, 3.9 mmol) was added and the reaction was protected under nitrogen. The reaction mixture was stirred at room temperature for 12 hours and then filtered. Subsequently, the solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 10:1 to 2:1) to afford thiophene-2-thiocarboxamide (1.0 g, 88.8% yield, white solid). Thiophene-2-carbothioamide can be used directly in the subsequent reaction without further purification.

References

[1] Patent: EP2708534, 2014, A1. Location in patent: Paragraph 0055
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 904 - 908
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 17, p. 7512 - 7523
[4] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9655 - 9662
[5] Journal of Chemical Research, 2010, # 3, p. 151 - 153

THIOPHENE-2-THIOCARBOXAMIDE(20300-02-1)Related Product Information

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