5-Cyanoindole CAS#: 15861-24-2

5-Cyanoindole

Basic information Safety Related Supplier

5-Cyanoindole Basic information

5-Cyanoindole Chemical Properties

Melting point:106-108 °C(lit.)
Boiling point:249.72°C (rough estimate)
Density 1.1777 (rough estimate)
refractive index 1.6211 (estimate)
storage temp. 0-6°C
form Crystalline Powder
color White to slightly yellow
Water Solubility Soluble in chloroform, hexane and methanol. Insoluble in water.
Sensitive Air & Light Sensitive
BRN 116738
CAS DataBase Reference15861-24-2(CAS DataBase Reference)

Safety Information

MSDS

5-Cyanoindole Usage And Synthesis

Chemical PropertiesOff-White Crystalline Powder
Uses• ;Reactant for parallel synthesis of dihydroisoquinolines via silver and L-proline co-catalyzed three-component coupling reaction1• ;Reactant for chemoselective and regioselective preparation of benzoyl indoles2• ;Reactant for preparation of novel PPARα/γ dual agonists for potential treatment of metabolic syndrome and IDDM3• ;Reactant for preparation of 4,5-dihydrocyclopenta[c]quinolines by palladium-catalyzed ring-expansion reaction alkynes, using O2 as the oxidant4• ;Reactant for preparation of vinylindoles by hydroarylation of alkynes using indium bromi
UsesInhibitor of enzyme.
Purification MethodsDissolve the nitrile in 95% EtOH, boil it in the presence of charcoal, filter, evaporate to a small volume and add enough H2O to cause crystallisation and cool. Recrystallise it directly from aqueous EtOH and dry it in a vacuum. UV has at max 276 nm (log 3.6) in MeOH. [Lindwall & Mantell J Org Chem 18 345 1953, 20 1458 1955, Thesing at al. Chem Ber 95 2205 1962, NMR: Lallemend & Bernath Bull Soc Chim Fr 4091 1970, Beilstein 22/3 V 45.]

5-Cyanoindole Preparation Products And Raw materials

5-Cyanoindole(15861-24-2)Related Product Information

5-CyanoindoleSupplierMore