5-Bromoindole Chemical Properties

Melting point:

90-92 °C (lit.)

Boiling point:

228.5°C (rough estimate)

Density 

1.5466 (rough estimate)

refractive index 

1.6550 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

126mg/l (calculated)

form 

Powder or Chunks

pka

16.04±0.30(Predicted)

color 

White to light brown

BRN 

112877

InChI

InChI=1S/C8H6BrN/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5,10H

InChIKey

VXWVFZFZYXOBTA-UHFFFAOYSA-N

SMILES

N1C2=C(C=C(Br)C=C2)C=C1

CAS DataBase Reference

10075-50-0(CAS DataBase Reference)

EPA Substance Registry System

1H-Indole, 5-bromo- (10075-50-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25-37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29339990

MSDS

• Language:English Provider:5-Bromo-1H-indole
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Bromoindole Usage And Synthesis

Chemical Properties

white to light brown powder or chunks

Uses

A potential inhibitor of GSK-3

Application

The 5-bromoindole is an important medicine intermediate that produces important source material for preventing and treating medicines such as cardiovascular disorders, sacred diseases, tumours and strengthening immunity. one of its important uses is the synthesis of indole derivative as tryptamines compounds, etc. These indole derivativeses are closely related with human vital movement, wherein melatonin and verivate thereof are regulated circadian rhythm, sleep, aspect such as antitumor very effectively.

Purification Methods

Purify it by steam distillation from a faintly alkaline solution. Cool the aqueous distillate, collect the solid, dry it in a vacuum desiccator over P2O5 and recrystallise it from aqueous EtOH (35% EtOH) or pet ether/Et2O. UV in MeOH has at 279, 287 and 296nm (log 3.70, 3.69 and 3.53). The picrate has m 137-138o(dec) (from max Et2O/pet ether). [UV: Thesing et al. Chem Ber 95 2205 1962, UV and NMR: Lallemand & Bernath Bull Soc Chim Fr 4091 1970, Beilstein 20/7 V 36.]

5-Bromoindole(10075-50-0)Related Product Information

• Indometacin
• Indole-3-acetic acid
• Indole-3-butyric acid
• Indole
• Ethyl 5-Bromoindole-2-carboxylate
• tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate
• (6-Methylpyridazin-3-yl)MethanaMine dihydrochloride
• No Chinese name
• rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl
• 5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE
• 1-METHYL-5-NITRO-1H-INDAZOLE
• 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester
• 5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE
• 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
• Pyrrolidine-3-carboxaMide hydrochloride
• 5-Bromoindazole
• (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate
• 2-cyclopylcyclopropane-1-carboxylic acid