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Phentolamine mesilate

Basic information Safety Supplier Related

Phentolamine mesilate Basic information

Product Name:
Phentolamine mesilate
Synonyms:
  • REGITIN
  • REGITIN MESYLATE
  • PHENTOLAMINE MESILATE
  • PHENTOLAMINE MESYLATE
  • PHENTOLAMINE METHANESULFONATE
  • PHENTOLAMINE METHANESULFONATE SALT
  • VASOMAX
  • m-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)-phenomonomethanesulfonate(sal
CAS:
65-28-1
MF:
C18H23N3O4S
MW:
377.46
EINECS:
200-604-6
Product Categories:
  • Adrenoceptor
  • Erectile Dysfunction
  • ACTIVE PHARMACEUTICAL INGREDIENTS
  • Diagnostic
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API
  • Pharmaceutical raw material
  • Regitine
  • pharmaceutical
Mol File:
65-28-1.mol
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Phentolamine mesilate Chemical Properties

Melting point:
180-182 °C(lit.)
Density 
1.2256 (rough estimate)
refractive index 
1.6320 (estimate)
storage temp. 
2-8°C
solubility 
ethanol: 26 mg/mL
form 
powder
color 
white to off-white
Water Solubility 
50 mg/mL
Merck 
14,7264
Stability:
Aq. Solutions Cannot be Stored
InChIKey
OGIYDFVHFQEFKQ-UHFFFAOYSA-N
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
RIDADR 
3249
WGK Germany 
3
RTECS 
SL5430000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29332900
Toxicity
LDLo scu-rat: 275 mg/kg NIIRDN 6,667,82

MSDS

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Phentolamine mesilate Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist with IC50 of 0.1 μM

Uses

Phentolamine Methanesulfonate Salt is an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.

Uses

As an adrenergic blocking agent and an antihypertensive, Phentolamine mesilate can be used for the treatment of pheochromocytoma.

brand name

Regitine (Novartis) [Name previously used: Phentolamine Methanesulfonate.].

General Description

Phentolamine Mesylate belongs to the class of alpha adrenergic antagonist drugs. It is used in the treatment of pheochromocytoma-related hypertension, erectile dysfunction and in the diagnosis of pheochromocytoma and norepinephrine-related dermal necrosis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

α-Adrenergic receptor antagonist; peripheral vasodilator.

Safety Profile

Poison by intravenous and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

Phentolamine mesilate Preparation Products And Raw materials

Raw materials

Phentolamine mesilateSupplier

Suzhou Unite pharmTech Co., Ltd , Gold
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792-3901125- ;
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sales@unite-pharm.com;tech@unite-pharm.com
Shanghai EFE Biological Technology Co., Ltd. Gold
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021-65675885
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Shanghai RC biotechnology Ltd. Gold
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1809424504@qq.com
Kono Chem Co.,Ltd Gold
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029-86107037-8009
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info@konochemical.com
Wuhan Biocar Pharmacy Co.,Ltd Gold
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2956176220@qq.com