2'-C-Methylcytidine Chemical Properties

Melting point:

243-245°C

Boiling point:

523.9±60.0 °C(Predicted)

Density 

1.72±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

H2O: >20mg/mL

pka

13.53±0.70(Predicted)

form 

powder

color 

white to off-white

InChIKey

PPUDLEUZKVJXSZ-VPCXQMTMSA-N

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

2'-C-Methylcytidine Usage And Synthesis

Description

2''-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity. It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC₅₀ values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC₅₀ = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC₅₀ = 2.2 μM) and human coronavirus (HCoV; EC₅₀ = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC₅₀ = 6.4 μM) and swine vesicular disease virus (SVDV; EC₅₀ = 45.2 μM). In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.

Chemical Properties

White to Off-White Powder

Uses

2’-C-Methyl Cytidine (cas# 20724-73-6) is a compound useful in organic synthesis.

Biochem/physiol Actions

2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase. 2′-C-Methylcytidine was the first nucleoside NS5B inhibitor that showed clinical efficacy. 2′-C-Methylcytidine was found to be effective against the 17D vaccine strain of yellow fever virus YFV in cell culture.

2'-C-Methylcytidine(20724-73-6)Related Product Information

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• 2'-C-Methylcytidine