Rosmantuzumab
Rosmantuzumab Basic information
- Product Name:
- Rosmantuzumab
- Synonyms:
-
- Rosmantuzumab
- Research Grade Rosmantuzumab (DHJ51101)
- Rosmantuzumab (anti-RSPO3)
- OMP-131R10
- Research Grade Rosmantuzumab
- CAS:
- 1684393-04-1
- MW:
- 0
- Mol File:
- Mol File
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Rosmantuzumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Rosmantuzumab Usage And Synthesis
Uses
Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors[1].
in vivo
Rosmantuzumab (25 mg/kg; i.p., once a week for 4 weeks) significantly protects the animals from developing liver fibrosis[1]. Rosmantuzumab (25 mg/kg; i.p., once for two weeks, for total 6 weeks) significantly inhibits skin thickness, collagen deposition, and number of α-SMA positive cells in bleomycin-induced lung fibrosis mouse models[1].
| Animal Model: | Male C57B1/6J CCl4 liver fibrosis mouse models[1] |
| Dosage: | 25 mg/kg |
| Administration: | Intraperitoneal injection; 25 mg/kg, once a week for 4 weeks |
| Result: | Significantly decreased collagen I and collagen III mRNAs, and inhibits β-catenin cytoplasmic and nuclear translocation. |
References
[1] Zhang M, et al. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. PLoS One. 2020 Mar 11;15(3):e0229445. DOI:10.1371/journal.pone.0229445
RosmantuzumabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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