Placulumab
Placulumab Basic information
- Product Name:
- Placulumab
- Synonyms:
-
- Placulumab
- Research Grade Placulumab
- CAS:
- 945781-29-3
- MW:
- 0
- Mol File:
- Mol File
More
Less
Placulumab Usage And Synthesis
Uses
Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis[1].
in vivo
Placulumab (0.3, 1, 3 and 10 mg/kg; i.p.; twice weekly for 8 weeks) has effective anti-arthritis properties in Tg197 transgenic mouse model[1].
Pharmacokinetic (PK) parameters of Placulumab in cynomolgus macaques[1]
| Route | Dose (mg/kg) | Exposure AUC0-336 h (ng.h/mL) | Maximum concentration Cmax (ng/mL) | Time of maximum concentration tmax (h) | Elimination half-life t1/2 (h) | Clearance CL (mL/hr/kg) |
| Intravenous injection (Males) | 50 | 46000000 | 1320000 | 0.167 | 104 | 0.985 |
| Intravenous injection (Females) | 50 | 43300000 | 1020000 | 0.211 | 97.4 | 1.06 |
| Route | Dose (mg/kg) | Exposure AUC0-336 h (ng.h/mL) | Dose normalize exposure AUC0-336 h (norm) | Maximum concentration Cmax (ng/mL) | Time of maximum concentration tmax (h) | Elimination half-life t1/2 (h) |
| Subcutaneous injection (Males) | 0.5 | 676000 | 1350000 | 3190 | 50.0 | 120 |
| Subcutaneous injection (Females) | 0.5 | 445000 | 890000 | 2880 | 48.0 | 108 |
| Subcutaneous injection (Males) | 5 | 3940000 | 788000 | 22700 | 40.0 | 117 |
| Subcutaneous injection (Females) | 5 | 3840000 | 767000 | 23800 | 12.0 | 109 |
| Subcutaneous injection (Males) | 50 | 41600000 | 832000 | 272000 | 40.0 | 122 |
| Subcutaneous injection (Females) | 50 | 32300000 | 646000 | 212000 | 32.0 | 107 |
References
[1] Gay RD, et al. Anti-TNFα domain antibody construct CEP-37247: Full antibody functionality at half the size. MAbs. 2010 Nov-Dec;2(6):625-38. DOI:10.4161/mabs.2.6.13493
PlaculumabSupplier
Wuhan Chemstan Biotechnology Co., Ltd.
- Tel
- 027-65317797 15926423062
- 422450190@qq.com
Biolab Reagents
- Tel
- 027-65279366 18108604356
- products@biolabreagent.com
Wuhan Jingkangen Biomedical Technology Co., Ltd
- Tel
- 13720134139 086-15871494362 13720134139
- orders@jknbiochem.com
Shanghai Yifei Biotechnology Co. , Ltd.
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
Changsha Fuzhen Biotechnology Co.，LTD
- Tel
- 0731-13823398 15111215862
- 313359644@qq.com