Avdoralimab
Avdoralimab Basic information
- Product Name:
- Avdoralimab
- Synonyms:
-
- Avdoralimab
- Research Grade Avdoralimab (DHD47201)
- Avdoralimab (anti-C5AR1)
- Research Grade Avdoralimab
- CAS:
- 2226393-85-5
- MW:
- 0
- Mol File:
- Mol File
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Avdoralimab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Avdoralimab Usage And Synthesis
Uses
Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research[1].
in vivo
In mice with a knock in for human C5aR1 (HuC5aR1 KI mice), Avdoralimab blocks the infiltration of neutrophils and monocytes, prevents albumin release in broncho-alveolar lavage fluid (BALF) and limits C5a-induced acute lung injury (ALI) histopathological features[1].
References
[1] Julien Carvelli, et al. Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis. Nature. 2020 Dec;588(7836):146-150. DOI:10.1038/s41586-020-2600-6
AvdoralimabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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Guangzhou Hongyuan Chemical Co.,Ltd
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- 15817493340
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Wuhan Chemstan Biotechnology Co., Ltd.
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- 027-65317797 15926423062
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TargetMol Chemicals Inc.
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