Desthiobiotin-PEG3-Amine Chemical Properties

Boiling point:

642.6±45.0 °C(Predicted)

Density 

1.074±0.06 g/cm3(Predicted)

pka

14.93±0.60(Predicted)

Desthiobiotin-PEG3-Amine Usage And Synthesis

Biological Activity

Amine-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Desthiobiotin-PEG3-Amine(2237234-71-6)Related Product Information

• Desthiobiotin-PEG3-DBCO
• Desthiobiotin-PEG3-NHS ester
• Azide-PEG3-Desthiobiotin
• Desthiobiotin-PEG3-Alkyne