4-Imidazolidinehexanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-5-methyl-2-oxo-, (4R,5S)- Chemical Properties

Boiling point:

666.0±50.0 °C(Predicted)

Density 

1.078±0.06 g/cm3(Predicted)

form 

Liquid

pka

14.93±0.60(Predicted)

color 

Colorless to light yellow

4-Imidazolidinehexanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-5-methyl-2-oxo-, (4R,5S)- Usage And Synthesis

Biological Activity

Amine-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

4-Imidazolidinehexanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-5-methyl-2-oxo-, (4R,5S)-(2306109-91-9)Related Product Information

• Desthiobiotin-PEG4-NHS ester
• Desthiobiotin-PEG4-Alkyne
• Desthiobiotin-PEG4-DBCO