2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one Chemical Properties

Boiling point:

352.5±37.0 °C(Predicted)

Density 

1.176±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

Store at room temperature

pka

11.13±0.40(Predicted)

form 

solid

Appearance

White to off-white Solid

InChI

InChI=1S/C9H10N2O2/c1-9(2)8(12)11-7-6(13-9)4-3-5-10-7/h3-5H,1-2H3,(H,10,11,12)

InChIKey

DMLNXUUGRSBBBR-UHFFFAOYSA-N

SMILES

O1C(C)(C)C(=O)NC2=NC=CC=C12

Safety Information

HS Code 

2934999090

2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one Usage And Synthesis

Synthesis

Step - (i): Synthesis of 2,2-dimethyl-2H-pyrido[3,2-B][1,4]oxazin-3(4H)-one (18.1) 2-Amino-3-hydroxypyridine (5 g, 45.45 mmol) was dissolved in acetone (50 mL) at 20-35 °C and stirred to form a solution. Subsequently K2CO3 (25.09g, 181.81mmol) was added followed by dropwise addition of ethyl 2-bromo-2-methylpropionate (13.29g, 68.18mmol). The reaction mixture was stirred at 70 °C for 16 hours. After completion of the reaction, the mixture was cooled to 20-35 °C and diluted with ice water. The resulting solid was collected by filtration and washed with water to afford the target compound as a white solid (5g, 97% yield). 1H NMR (400MHz, DMSO-d6): [specific NMR data should be added here].

References

[1] Patent: WO2015/71780, 2015, A1. Location in patent: Page/Page column 22
[2] Tetrahedron Letters, 2010, vol. 51, # 14, p. 1852 - 1855
[3] Acta Chemica Scandinavica (1947-1973), 1969, vol. 23, p. 2322 - 2324

2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one(20348-21-4)Related Product Information

• 2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one
• 2-METHYL-N-(3-MORPHOLINOPROPYL)-3-OXO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE-2-CARBOXAMIDE
• 6-AMINO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
• 2,2-DIMETHYL-6-NITRO-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
• 7-AMINO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
• 2-METHYL-3-OXO-N-(TETRAHYDRO-2-FURANYLMETHYL)-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE-2-CARBOXAMIDE
• 2-METHYL-3-OXO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE-2-CARBOXYLIC ACID
• ETHYL 2-METHYL-3-OXO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE-2-CARBOXYLATE
• 2,2-DIMETHYL-7-NITRO-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
• N-(3,4-DICHLOROBENZYL)-2-METHYL-3-OXO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE-2-CARBOXAMIDE
• N-(2-METHOXYBENZYL)-2-METHYL-3-OXO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE-2-CARBOXAMIDE