N-Eicosanoyl Serotonin Chemical Properties

storage temp. 

-20°

solubility 

Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming)

form 

solid

color 

Beige

Stability:

Stable for 2 years from date of purchase supplied. Protect from air. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

N-Eicosanoyl Serotonin Usage And Synthesis

Description

N-Eicosanoyl serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy.1 It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated α-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. ?It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease.2,3

Uses

N-Eicosanoyl Serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy. It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease

References

[1] RUN YAN. Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2018: E12053-E12062. DOI:10.1073/pnas.1813365115
[2] KESAVA ASAM. Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.[J]. PLoS ONE, 2017: e0189413. DOI:10.1371/journal.pone.0189413
[3] GUSTAVO BASURTO-ISLAS . Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease[J]. Neurobiology of Aging, 2014, 35 12: Pages 2701-2712. DOI:10.1016/j.neurobiolaging.2014.06.012

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