Trk B Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

biological source

rabbit

Specific Activity

63-85nmol/min·mg

Safety Information

Hazard Codes 

T

Risk Statements 

61

Safety Statements 

53-45

Trk B Usage And Synthesis

Uses

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Biological Activity

TRKC is a member of the TRK family of tyrosine kinase receptors and is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). TRKC mediates the multiple cellular effects of the NT-3 neurotrophic factor, which includes neuronal differentiation and survival. TRKC has been implicated in insulin signaling pathway through interactions with the MUSK protein receptor and the VEGF receptor. Mutations in the TRKC gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

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