PREALBUMIN, HUMAN Chemical Properties

storage temp. 

2-8°C

solubility 

H2O: soluble1mg/mL

form 

lyophilized powder

biological source

human plasma

Water Solubility 

H2O: soluble 1mg/mL

ε(extinction coefficient)

13.5 at 280nm at 1%

Safety Information

Hazard Codes 

B

WGK Germany 

1

F 

10-21

MSDS

• Language:English Provider:SigmaAldrich

PREALBUMIN, HUMAN Usage And Synthesis

Uses

Prealbumin from human plasma has been used as a positive control in immunoprecipitation as a reference standard in quantitative rocket immunoelectrophoresis for quantification of cerebrospinal fluid.

General Description

Native prealbumin from human plasma. Plasma protein with minimal carbohydrate. Found in plasma at about 30 mg/100 ml. Functions in the transport of retinol-binding protein, thyroxine, and vitamin A.

Biochem/physiol Actions

Prealbumin levels are indictors of malnutrition and may be modulated during inflammation. It is regarded as potential marker of protein energy malnutrition (PEM) during chronic kidney failure supported dialysis. Low levels of prealbumin poses high risk to heart failure (HF).

Description

Transthyertin Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 128 amino acids (21-147 a.a.) and having a molecular weight of 13.8kDa. The Transthyertin is purified by proprietary chromatographic techniques.

Source

Human serum

Background

Prealbumin is a  thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. Prealbumin is a carrier protein which transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. Transthyretin consists of a tetramer of identical subunits and is dominantly produced in the liver. Mutations in Prealbumin are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. Prealbumin is an indicator of protein-energy malnutrition since it has a circulating half life of 2 days and reacts swiftly to changes in nutritional status.

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