1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE Chemical Properties

Boiling point:

260.0±40.0 °C(Predicted)

Density 

1.590±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

solid

InChI

1S/C9H8BrFO2/c10-6-1-2-8(11)7(5-6)9-12-3-4-13-9/h1-2,5,9H,3-4H2

InChIKey

WWJNPWYIXIIEJG-UHFFFAOYSA-N

SMILES

FC1=CC=C(C=C1C2OCCO2)Br

Safety Information

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE Usage And Synthesis

Uses

1,1-Diethoxyethylene can be used as a pharmaceutical synthesis intermediate, such as in the preparation of the compound (3-[1,3]dioxolane-2-yl-4-fluoro-phenyl)-(8-nitro-quinoline-7-yl)-methanol. The specific steps are as follows: Magnesium (983 mg, 40.5 mmol) is suspended in anhydrous THF (30 ml). 1,2-Dibromoethane (0.17 ml, 2.02 mmol) is added, and the solution is stirred at room temperature for 20 minutes. 1,1-Diethoxyethylene (3.2 g, 1.295 mmol) is added dropwise, and the mixture is heated at 40 °C for 2 hours. After cooling to room temperature, Grignard reagent (0.43 M; 28.6 ml) is added at 0 °C to the anhydrous THF (30 ml) suspension of 8-nitroquinoline-7-carboxaldehyde 204 (2.5 g, 1.28 mmol).

Application

1,1-Diethoxyethylene can be used as a pharmaceutical synthesis intermediate.

1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE(679840-30-3)Related Product Information

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