- Product Name:
- ETHYLENE OXIDE
- ETHYLENE OXIDE, 99.5+%
- ETHYLENE OXIDE CYLINDER WITH 2 L (NET ~1 .5 KG)
- ETHYLENE OXIDE, 1X1ML, MEOH, 50000UG/ML
- ETHYLENE OXIDE 1X1ML, CH2CL2, 2000UG/ML
- ETHYLENE OXIDE, CYLINDER WITH 27 L (NET ~20 KG)
- ETHYLENE OXIDE, 1X1ML, CH2CL2, 50000UG/M L
- ETHYLENE OXIDE, PRESSURE TIN WITH 250 ML (NET ~225 G)
- ethylene oxide solution
- Product Categories:
- Simple 3-Membered Ring Compounds
- EQ - EZPesticides
- General Use
- Air Monitoring Standards
- Alpha Sort
- Volatiles/ Semivolatiles
- Chemical Synthesis
- Specialty Gases
- Synthetic Reagents
- Mol File:
ETHYLENE OXIDE Chemical Properties
- Melting point:
- −111 °C(lit.)
- Boiling point:
- 10.7 °C(lit.)
- 0.882 g/mL at 25 °C(lit.)
- vapor pressure
- 1095 mmHg at 20 °C
- refractive index
- n20/D 1.3597(lit.)
- Flash point:
- storage temp.
- Sweet odor detectable at 257 to 690 ppm
- Exposure limits
- TLV-TWA 1.8 mg/m3 (1 ppm) (ACGIH), 0.18 mg/m3 (0.1 ppm), 5 ppm/10 min (NIOSH).
- CAS DataBase Reference
- 75-21-8(CAS DataBase Reference)
- Hazard Codes
- Risk Statements
- Safety Statements
- UN 2037 2.3
- WGK Germany
- Autoignition Temperature
- 429 °C
- HS Code
- LD50 oral (rat) 72 mg/kg
LC50 inhal (rat) 800 ppm (1600 mg/m3)
PEL (OSHA) 1 ppm (2 mg/m3)
TLV-TWA (ACGIH) 1 ppm (2 mg/m3)
- Language:English Provider:SigmaAldrich
ETHYLENE OXIDE Usage And Synthesis
Ethylene oxide (C2H4O) is a kind of cyclic ether with important industrial applications. Although it is highly toxic and dangerous for household application and consumers to use, it can be used for the manufacture of many important industrial and commercialized products as well as some chemicals and intermediates. For example, it is very useful in the production of detergents, thickeners, solvents, plastics, and many kinds of organic chemicals such as ethylene glycol, ethanolamines, simple and complex glycols, polyglycol ethers, and other compounds. It is also a commonly sterilization methods used in the healthcare industry. In addition, it can be used as an accelerator of maturation of tobacco leaves and fungicide, as well as the main component of thermobaric weapons (fuel-air explosives). In industry, it is generally manufactured through direct oxidation of ethylene. In low doses, it can be used as a pesticide and a sterilizing agent owing to its effect of causing DNA damage. However, this property also make it a potential carcinogen.
ethylene oxide structure
Ethylene oxide is the simplest cyclic ether. It is a colorless gas or liquid and has a sweet, etheric odor. Ethylene oxide is a flammable, very reactive and explosive chemical substance. On decomposition, vapors of pure ethylene oxide mix with air or inert gases and become highly explosive. Ethylene oxide, is used in large scale as an intermediate in the production of monoethylene glycol, diethylene glycol, triethylene glycol, poly(ethylene) glycols, ethylene glycol ethers, ethanolamine, ethoxylation products of fatty alcohols, fatty amines, alkyl phenols, cellulose, and poly(propylene glycol). It is also used as a fumigant for food and cosmetics, and in hospital sterilization of surgical equipment and heat sensitive materials.
Reported found in Bantu beer.
Ethylene oxide is widely used as a sterilizingagent; as a fumigant; as a propellant; in theproduction of explosives; in the manufactureof ethylene glycol, polyethylene oxide, gly-col ethers, crown ethers, ethanolamines, andother derivatives; and in organic synthesis.
The major use of ethylene oxide in the United States (accounting for over 99% of production) is as an intermediate in the production of several industrial chemicals (ATSDR 1990, IARC 1994). The remainder is used in the gaseous form, either alone or combined with nitrogen, carbon dioxide, or dichlorofluoromethane as a sterilizing agent, disinfectant, fumigant, or insecticide. The largest use (about 60%) is to produce ethylene glycol (antifreeze). Other chemicals produced from ethylene oxide include non-ionic surfactants (used in industrial applications, detergents, and dishwashing formulations), glycol ethers, ethanolamines (used in soaps, detergents, and textile chemicals), diethylene glycol, triethylene glycol, polyethylene glycol, and urethane polyols. Although a relatively small percentage of ethylene oxide is used as a fumigant or sterilizing agent, these uses involve a variety of facilities, products, and materials, including hospital equipment, medical and dental clinics, research laboratories, foods, furs, clothing, furniture, books, paper, leather, cosmetics, drugs, railroad cars, beehives, and tobacco. Facilities that manufacture sterile disposable medical supplies and medical facilities, including hospitals, medical and dental clinics, and private medical and dental surgeries, account for about 95% of the ethylene oxide used as a fumigant or sterilant. In hospitals, ethylene oxide is used as a gaseous sterilant for heatsensitive medical items, surgical instruments, and other objects and fluids coming in contact with biological tissues. Before 1966, ethylene oxide was used as an intermediate in the production of acrylonitrile.
Fumigant for foodstuffs and textiles; to sterilize surgical instruments; agricultural fungicide. In organic syntheses, especially in the production of ethylene glycol. Starting material for the manufacture of acrylonitrile and nonionic surfactants.
ChEBI: A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom.
By catalytic oxidation of ethylene.
Aroma threshold values
Detection: 260 ppm; recognition: 500 ppm
Air & Water Reactions
Highly flammable. Flammable over a wide vapor-air concentration range. Must be diluted on the order of 24 to 1 with water to lose flammability. Soluble in water.
Colorless gas at room temperature (b.p. 11°C), confirmed carcinogen. Highly flammable, severe explosion hazard when exposed to flame. The autoignition temperature may be as low as 140° C in presence of rust. Rapid compression of the vapor with air causes explosion. ETHYLENE OXIDE vapor may be initiated into explosive decomposition in absence of air [Hess, L. G., et al., Ind. Eng. Chem., 1950, 42, p. 1251]. Metal fittings containing magnesium, copper or silver should be avoided, since traces of acetylene in ETHYLENE OXIDE may produce metal acetylides capable of detonating the vapor [MCA SD-38, 1971]. Violent polymerization occurs on contact with strong bases (alkali hydroxides, ammonia) or acids, amines, metallic potassium, oxides (aluminum oxide, iron oxide, rust), covalent halides (aluminum chloride, ferric chloride, tin(IV) chloride) [Gupta, A. K., J. Soc. Chem. Ind., 1949, 68, p. 179]. Violent reaction with m-nitroaniline, magnesium perchlorate, mercaptans, thiols, triethylamine [Bretherick, 5th ed., 1995, p. 316]. ETHYLENE OXIDE and SO2 can react violently in pyridine solution with pressurization if ETHYLENE OXIDE is in excess (Nolan, 1983, Case History 51).
Irritant to eyes and skin. Confirmed carcinogen. Highly flammable, dangerous fire and explosion risk, flammable limits in air 3–100%.
Ethylene oxide is a severe irritant, as well asa toxic and carcinogenic compound. Inhala-tion can cause severe irritation in the eyes,respiratory tract, and skin. In humans, thedelayed symptoms may be nausea, vomit-ing, headache, dyspnea, pulmonary edema,weakness, and drowsiness. Exposure to highconcentrations can cause central nervous sys-tem depression.
Contact with an aqueous solution of ethy-lene oxide on skin can produce severe burnsafter a delay period of a few hours. It maybe absorbed by plastic, leather, and rubbermaterials if not handled properly, and cancause severe skin irritation.
Exposure of test animals to a high con-centration of ethylene oxide resulted inthe watering of eyes, nasal discharge, and labored breathing. The toxic effects observedafter a few days were vomiting, diarrhea,pulmonary edema, dyspnea, and convulsion,followed by death.
Ethylene oxide is a teratogen, causingbirth defects. Laboratory tests on animalsindicated that exposure could cause fetaldeaths, specific developmental abnormalities,and paternal effects related to testes andsperm ducts.
Ethylene oxide showed positive carcino-genicity in test animals. Inhalation, ingestion,and subcutaneous application over a periodof time developed tumors of all kinds in ratsand mice. It caused brain, liver, gastroin-testinal, and blood cancers in test subjects.Ethylene oxide and 1,2- propylene oxideeach mixed with salad oil induced squamous-cell carcinomas of the forestomach whenadministered intra-gastrically by gavage tofemale Sprague-Dawley rats (Dunkelberg1982). The study was carried out for a periodof 3 years and the first tumor occurred inthe 79th week for both compounds. Nei-ther compound, however, induced tumors atsites away from the point of administration.Experimental studies on rodents indicatedthat subacute exposures to ethylene oxideat a concentration of 1 ppm caused DNAdamage producing the DNA adduct, 7-(2-hydroxyethyl)guanine (Thier and Bolt 2000).Although the evidence of its carcinogenicityin humans is inadequate, it is suspected to becancer causing to humans.
Ethylene oxide is a mutagen in animalsand humans. It causes chromosomal aber-rations (Thiess et al. 1981), errors in DNAsynthesis (Cumming et al. 1981), and alky-lation of hemoglobin (Calleman et al. 1978).
Repeated brief exposures to ethylene oxideat 800 and 1200 ppm caused fetal toxicityindicated by reduced fetal weight in rats(Saillenfait et al. 1996).
Flammability and Explosibility
Ethylene oxide is an extremely flammable substance (NFPA rating = 4). Ethylene oxide vapor may be ignited by hot surfaces such as hot plates and static electricity discharges, and since the vapor is heavier than air, it may travel a considerable distance to an ignition source and flash back. Ethylene oxide vapor forms explosive mixtures with air at concentrations of 3 to 100% (by volume). Carbon dioxide or dry chemical extinguishers should be used for ethylene oxide fires. Ethylene oxide may explode when heated in a closed vessel.
Fungicide and fumigant: Ethylene oxide is used as a fumigant for spices, seasonings, and foodstuffs and as an agricultural fungicide. When used directly in the gaseous form or in nonexplosive gaseous mixtures with nitrogen or carbon dioxide, ethylene oxide can act as a disinfectant, fumigant, sterilizing agent, and insecticide. It is a man-made chemical used as an intermediate in organic synthesis for ethylene glycol, polyglycols, glycol ethers, esters, ethanolamines, acrylonitrile, plastics, and surface-active agents. It is also used as a fumigant for textiles and for sterilization, especially for surgical instruments. It is used in drug synthesis and as a pesticide intermediate. Not approved for use in EU countries. Actively registered in the U.S.
AMPROLENE®; ANPROLENE®; ANPROLINE®; BIODAC®; MERPOL®; OXYFUME®; OXYFUME 12®; T-GAS®; STERILIZING GAS ETHYLENE OXIDE 100%®
Ethylene oxide is a very strong irritant widely used in the chemical industry, and as a sterilizer of medical supplies, pharmaceutical products, and food. It can produce immediate (urticaria, asthma, anaphylaxis) or delayed reactions (irritant rather than allergic contact dermatitis). For example, residues in masks or dressings can produce irritant contact dermatitis.In delayed contact allergy, it seems that cross-reaction can be observed to epichlorhydrin or epoxypropane
Confirmed human carcinogen with experimental carcinogenic, tumorigenic, neoplastigenic, and teratogenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Human systemic effects by inhalation: convulsions, nausea, vomiting, olfactory and pulmonary changes. Experimental reproductive effects. Mutation data reported. A skin and eye irritant. An irritant to mucous membranes of respiratory tract. High concentrations can cause pulmonary edema. Highly flammable liquid or gas. Severe explosion hazard when exposed to flame. To fight fire, use alcohol foam, CO2, dry chemical. Violent polymerization occurs on contact with ammonia, alkali hydroxides, amines, metalllc potassium, acids, covalent halides (e.g., aluminum chloride, iron(Ⅲ) chloride, tin(rv> chloride, aluminum oxide, iron oxide, rust). Explosive reaction with glycerol at 200℃. Rapid compression of the vapor with air causes explosions. Incompatible with bases, alcohols, air, m-nitroanlline, trimethyl amine, copper, iron chlorides, iron oxides, magnesium perchlorate, mercaptans, potassium, tin chlorides, contaminants, alkane thols, bromoethane. When heated to decomposition it emits acrid smoke and irritating fumes.
Ethylene oxide is a man-made chemical used in the production of glycols (ethylene glycol, polyglycols, glycol ethers, esters), nontonic surface-active agent; ethanolamines, acrylonitrile, plastics. It is also used as a fumigant for foodstuffs and textiles; an agricultural fungicide; and for sterilization, especially for surgical instruments. It is used in drug synthesis and as a pesticide intermediate
Ethylene oxide is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans, including epidemiological studies and studies on mechanisms of carcinogenesis. Ethylene oxide was first listed in the Fourth Annual Report on Carcinogens in 1985 as reasonably anticipated to be a human carcinogen based on limited evidence of carcinogenicity from studies in humansand sufficient evidence of carcinogenicity from studies in experimental animals. The listing was revised to known to be a human carcinogen in the Ninth Report on Carcinogens in 2000.
An increased risk of cancer has been demonstrated in epidemiological studies of workers using ethylene oxide as a sterilant for medical devices and spices and in chemical synthesis and production.Evidence for a common mechanism of carcinogenesis in humans and experimental animals comes from studies that have found similar genetic damage in cells of animals and workers exposed to ethylene oxide. The DNA-damaging activity of ethylene oxide explains its effectiveness as a sterilant, and this same property accounts for its carcinogenic risk to humans.
work with ethylene oxide should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and splash goggles should be worn at all times to prevent skin and eye contact. Ethylene oxide should be used only in areas free of ignition sources and should be stored in the cold in tightly sealed containers placed within a secondary container.
UN1040 Ethylene oxide or Ethylene oxide with nitrogen up to a total pressure of 1 MPa (10 bar) at 50℃, Hazard Class: 2.3; Labels: 2.3-Poisonous gas, 2.1- Flammable gas, Inhalation Hazard Zone D. Cylinders must be transported in a secure upright position, in a wellventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner
Dry oxirane with CaSO4, then distil it from crushed NaOH. It has also been purified by passage, as a gas, through towers containing solid NaOH. [Beilstein 17/1 V 3.]
May form explosive mixture with air. Chemically unstable. Dangerously reactive; may rearrange chemically and/or polymerize violently with evolution of heat; when in contact with highly active catalytic surfaces, such as anhydrous chlorides of iron, tin and aluminum; pure oxides of iron and aluminum; and alkali metal hydroxides. Even small amounts of strong acids; alkalis, or oxidizers can cause a reaction. Avoid contact with copper. Protect container from physical damage, sun and heat. Attacks some plastics, rubber or coatings.
Return refillable compressed gas cylinders to supplier. Concentrated waste containing no peroxides-discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides-perforation of a container of the waste from a safe distance followed by open burning
Ethylene oxide is dangerously explosive under fi re condition; it is flammable over an extremely large range of concentrations in air and burns in the absence of oxygen.
Coast Guard, Department of Homeland Security
Minimum requirements have been established for safe transport of ethylene oxide on ships and barges.
Department of Transportation (DOT)
Ethylene oxide mixtures are considered hazardous materials, and special requirements have been set for marking, labeling, and transporting these materials.
Environmental Protection Agency (EPA)
Clean Air Act
National Emissions Standards for Hazardous Air Pollutants: Listed as a hazardous air pollutant.
New Source Performance Standards: Manufacture of ethylene oxide is subject to certain provisions for the control of volatile organic compound emissions. Prevention of Accidental Release: Threshold quantity (TQ) = 10,000 lb. Urban Air Toxics Strategy: Identified as one of 33 hazardous air pollutants that present the greatest threat to public health in urban areas.
Comprehensive Environmental Response, Compensation, and Liability Act
Reportable quantity (RQ) = 1 lb.
Emergency Planning and Community Right-To-Know Act
Toxics Release Inventory: Listed substance subject to reporting requirements.
Threshold planning quantity (TPQ) = 1,000 lb.
Reportable quantity (RQ) = 10 lb.
Federal Insecticide, Fungicide, and Rodenticide Act
The tolerance for residues of ethylene oxide when used as a fumigant on coconut, walnuts, and spices = 50 ppm.
ETHYLENE OXIDE Preparation Products And Raw materials
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