2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Chemical Properties

Melting point:

320° (dec)

Density 

1.527

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Soluble in DMSO

form 

solid

pka

7.44±0.10(Predicted)

color 

Yellow

λmax

284nm(MeOH)(lit.)

Merck 

14,3584

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

HS Code 

2933.59.9500

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Usage And Synthesis

Description

Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1-3? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.

Uses

Potent inactivator of Dihydropyrimidine dehydrogenase (DPD).

Definition

ChEBI: Eniluracil is a pyrimidone.

References

1) Porter?et al. (1992),?Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem.,?267?5236 2) Baccalnari?et al. (1993),?5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA,?90?11064 3) Schilsky and Kindler (2000)?Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs,?9?1635

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