2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

Product Name: 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
CAS No.: 59989-18-3
Chemical Name: 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
Synonyms: GW-776;GW776C85;ADH-300004;NSC 687296;5-ethynyluracil;5-Ethynyluracil>Eniluracil (5-Ethynyluracil;5-Ethynyl-1H-pyrimidine-2,4-dione;5-Ethynyl-2,4(1H,3H)-pyriMidinedione;5-EthynylpyriMidine-2,4(1H,3H)-dione
CBNumber: CB61081129
Molecular Formula: C6H4N2O2
Formula Weight: 136.11
MOL File: 59989-18-3.mol

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2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Property

Melting point:: 320° (dec)
Density: 1.527
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO
form: solid
pka: 7.44±0.10(Predicted)
color: Yellow
λmax: 284nm(MeOH)(lit.)
Merck: 14,3584
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

HS Code: 2933.59.9500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1096
Product name: 5-Ethynyluracil
Purity: >97.0%(HPLC)(T)
Packaging: 200mg
Price: $201
Updated: 2024/03/01

TCI Chemical

Product number: E1096
Product name: 5-Ethynyluracil
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $696
Updated: 2024/03/01

TRC

Product number: E558650
Product name: Eniluracil
Packaging: 10mg
Price: $55
Updated: 2021/12/16

TRC

Product number: E558650
Product name: Eniluracil
Packaging: 1g
Price: $495
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005199
Product name: ENILURACIL
Purity: 95.00%
Packaging: 100MG
Price: $779.63
Updated: 2021/12/16

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2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Chemical Properties,Usage,Production

Description

Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1-3? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.

Uses

Potent inactivator of Dihydropyrimidine dehydrogenase (DPD).

Definition

ChEBI: Eniluracil is a pyrimidone.

References

1) Porter?et al. (1992),?Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem.,?267?5236 2) Baccalnari?et al. (1993),?5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA,?90?11064 3) Schilsky and Kindler (2000)?Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs,?9?1635

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Suppliers

Americas 1 Canada 1 China 41 Europe 2 India 3 Japan 1 United Kingdom 4 United States 12 Global 65

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59989-18-3, 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)Related Search:

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5-ethynyluracil

5-Ethynyl-2,4(1H,3H)-pyriMidinedione

NSC 687296

GW776C85

ADH-300004

GW-776

5-EthynylpyriMidine-2,4(1H,3H)-dione

5-Ethynyl-1H-pyrimidine-2,4-dione

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

5-Ethynyluracil&gt

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl-

Eniluracil (5-Ethynyluracil

5-fluorouracil,cancer,Inhibitor,inhibit,Eniluracil,5-FU,tumor,combination

59989-18-3

Nucleotides

Pharmaceuticals

PYRIMIDINE

Bases & Related Reagents

Intermediates & Fine Chemicals