ChemicalBook > CAS DataBase List > 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

Product Name
2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
CAS No.
59989-18-3
Chemical Name
2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
Synonyms
GW-776;776C85;GW776C85;PCS-6422;ADH-300004;NSC 687296;BW-776-C85;5-ethynyluracil;5-Ethynyluracil>Eniluracil, 10 mM in DMSO
CBNumber
CB61081129
Molecular Formula
C6H4N2O2
Formula Weight
136.11
MOL File
59989-18-3.mol
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2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Property

Melting point:
320° (dec)
Density 
1.527
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO
form 
solid
pka
7.44±0.10(Predicted)
color 
Yellow
λmax
284nm(MeOH)(lit.)
Merck 
14,3584
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

HS Code 
2933.59.9500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
E1096
Product name
5-Ethynyluracil
Purity
>97.0%(HPLC)(T)
Packaging
200mg
Price
$203
Updated
2025/07/31
TCI Chemical
Product number
E1096
Product name
5-Ethynyluracil
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$704
Updated
2025/07/31
TRC
Product number
E558650
Product name
Eniluracil
Packaging
10mg
Price
$55
Updated
2021/12/16
TRC
Product number
E558650
Product name
Eniluracil
Packaging
1g
Price
$495
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005199
Product name
ENILURACIL
Purity
95.00%
Packaging
100MG
Price
$779.63
Updated
2021/12/16
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2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Chemical Properties,Usage,Production

Description

Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1-3? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.

Uses

Potent inactivator of Dihydropyrimidine dehydrogenase (DPD).

Definition

ChEBI: Eniluracil is a pyrimidone.

in vivo

Eniluracil (5-Ethynyluracil) (1 mg/kg; i.p.; single daily for 3 days) exhibits neither toxicity nor intrinsic antitumor activity, and greatly improves FUra (5-fluorouracil) therapy in rats[1].

Animal Model:Female Fischer 344/HSD rats (6 to 7-week-old; 150-200 g)[1].
Dosage:1 mg/kg
Administration:Intraperitoneal injection; single daily for 3 days (l h before FUra (5-fluorouracil) and for an additional 2 days after FUra therapy)
Result:Produced complete tumor regression that was sustained for at least 90 days posttherapy when combined with 3.5 mg/kg FUra, however, 35 mg/kg FUra alone produced partial responses in 75% of the treated animals ( the tumors regrew in all of these animals).

References

[1] D J PORTER. Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil.[J]. The Journal of Biological Chemistry, 1992, 267 8: 5236-5242.
[2] D P BACCANARI. 5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1993, 90 23: 11064-11068. DOI:10.1073/pnas.90.23.11064
[3] R L SCHILSKY  H L K. Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase.[J]. Expert opinion on investigational drugs, 2000, 9 7: 1635-1649. DOI:10.1517/13543784.9.7.1635

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Suppliers

Americas 1 Canada 1 China 60 Europe 2 India 3 Japan 1 United Kingdom 4 United States 12 Global 84
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75

59989-18-3, 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)Related Search:

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  • 5-ethynyluracil
  • 5-Ethynyl-2,4(1H,3H)-pyriMidinedione
  • NSC 687296
  • GW776C85
  • ADH-300004
  • GW-776
  • 5-EthynylpyriMidine-2,4(1H,3H)-dione
  • 5-Ethynyl-1H-pyrimidine-2,4-dione
  • 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
  • 5-Ethynyluracil&gt
  • 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl-
  • Eniluracil (5-Ethynyluracil
  • 5-fluorouracil,cancer,Inhibitor,inhibit,Eniluracil,5-FU,tumor,combination
  • Eniluracil, 10 mM in DMSO
  • BW-776-C85
  • PCS-6422
  • 776C85
  • 59989-18-3
  • Nucleotides
  • Pharmaceuticals
  • PYRIMIDINE
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals