ChemicalBook > CAS DataBase List > 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

Product Name
2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
CAS No.
59989-18-3
Chemical Name
2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
Synonyms
GW-776;GW776C85;ADH-300004;NSC 687296;5-ethynyluracil;5-Ethynyluracil>Eniluracil (5-Ethynyluracil;5-Ethynyl-1H-pyrimidine-2,4-dione;5-Ethynyl-2,4(1H,3H)-pyriMidinedione;5-EthynylpyriMidine-2,4(1H,3H)-dione
CBNumber
CB61081129
Molecular Formula
C6H4N2O2
Formula Weight
136.11
MOL File
59989-18-3.mol
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2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Property

Melting point:
320° (dec)
Density 
1.527
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO
form 
solid
pka
7.44±0.10(Predicted)
color 
Yellow
λmax
284nm(MeOH)(lit.)
Merck 
14,3584
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

HS Code 
2933.59.9500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
E1096
Product name
5-Ethynyluracil
Purity
>97.0%(HPLC)(T)
Packaging
200mg
Price
$201
Updated
2024/03/01
TCI Chemical
Product number
E1096
Product name
5-Ethynyluracil
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$696
Updated
2024/03/01
TRC
Product number
E558650
Product name
Eniluracil
Packaging
10mg
Price
$55
Updated
2021/12/16
TRC
Product number
E558650
Product name
Eniluracil
Packaging
1g
Price
$495
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005199
Product name
ENILURACIL
Purity
95.00%
Packaging
100MG
Price
$779.63
Updated
2021/12/16
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2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Chemical Properties,Usage,Production

Description

Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1-3? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.

Uses

Potent inactivator of Dihydropyrimidine dehydrogenase (DPD).

Definition

ChEBI: Eniluracil is a pyrimidone.

References

1) Porter?et al. (1992),?Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem.,?267?5236 2) Baccalnari?et al. (1993),?5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA,?90?11064 3) Schilsky and Kindler (2000)?Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs,?9?1635

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Suppliers

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59989-18-3, 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)Related Search:

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  • 5-ethynyluracil
  • 5-Ethynyl-2,4(1H,3H)-pyriMidinedione
  • NSC 687296
  • GW776C85
  • ADH-300004
  • GW-776
  • 5-EthynylpyriMidine-2,4(1H,3H)-dione
  • 5-Ethynyl-1H-pyrimidine-2,4-dione
  • 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
  • 5-Ethynyluracil&gt
  • 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl-
  • Eniluracil (5-Ethynyluracil
  • 5-fluorouracil,cancer,Inhibitor,inhibit,Eniluracil,5-FU,tumor,combination
  • 59989-18-3
  • Nucleotides
  • Pharmaceuticals
  • PYRIMIDINE
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals