Triciribine Chemical Properties

Density 

2.23

solubility 

PBS (pH 7.2): 10 mg/ml

form 

Solid

color 

Light yellow to yellow

Triciribine Usage And Synthesis

Uses

Triciribine phosphate is an Akt activation inhibitor that inhibits Akt phosphorylation by binding to the pleckstrin homology (PH) domain of the Akt and blocking its recruitment to the plasma membrane.

brand name

Triciribine is INN.

References

[1] N BERNDT. The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane[J]. Cell Death and Differentiation, 2010, 17 11: 1795-1804. DOI: 10.1038/cdd.2010.63
[2] PLAGEMANN P G. Transport, phosphorylation, and toxicity of a tricyclic nucleoside in cultured Novikoff rat hepatoma cells and other cell lines and relase of its monophosphate by the cells.[J]. JNCI Journal of the National Cancer Institute, 1976, 57 6: 1283-1295. DOI: 10.1093/jnci/57.6.1283
[3] B C BEHRENS. Activity of tricyclic nucleoside 5’-phosphate in model systems of human ovarian cancer.[J]. Investigational New Drugs, 1986, 4 4: 295-304. DOI: 10.1007/bf00173502
[4] ANTHONY R. PORCARI. Deoxy Sugar Analogues of Triciribine: Correlation of Antiviral and Antiproliferative Activity with Intracellular Phosphorylation[J]. Journal of Medicinal Chemistry, 2000, 43 12: 2438-2448. DOI: 10.1021/jm990205m

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