DMT-dA(bz) Phosphoramidite CAS#: 98796-53-3

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DMT-dA(bz) Phosphoramidite

Basic information Physical form Color Safety Supplier Related

DMT-dA(bz) Phosphoramidite Basic information

Product Name:

DMT-dA(bz) Phosphoramidite

Synonyms:

DMT-dA(bz) PhosphoraMidite
N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine 5'-CE phosphoramidite
N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-CE phosphoramidite
2'DEOXYADENOSINE PHOSPHORAMADITE
2'-DEOXYADENOSINE PHOSPHORAMIDITE
dA(N-Bz) Phosphoramidite
N-blocked-5'-O-DMT 3'-CED deoxyadenosine phosphoramidite
(2R,3S,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite

CAS:

98796-53-3

MF:

C47H52N7O7P

MW:

857.93

EINECS:

685-521-7

Product Categories:

Pharmaceutical
RNAi
Amidite

Mol File:

98796-53-3.mol

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DMT-dA(bz) Phosphoramidite Chemical Properties

Density: 1.23 at 20℃
vapor pressure: 0-0Pa at 20-50℃
storage temp.: Sealed in dry,2-8°C
solubility: soluble, clear
form: powder or granules
pka: 7.87±0.43(Predicted)
color: white to off-white
InChI: InChI=1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(59-27-13-26-48)61-40-28-42(53-31-51-43-44(49-30-50-45(43)53)52-46(55)34-14-9-7-10-15-34)60-41(40)29-58-47(35-16-11-8-12-17-35,36-18-22-38(56-5)23-19-36)37-20-24-39(57-6)25-21-37/h7-12,14-25,30-33,40-42H,13,27-29H2,1-6H3,(H,49,50,52,55)/t40-,41+,42+,62?/m0/s1
InChIKey: GGDNKEQZFSTIMJ-AKWFTNRHSA-N
SMILES: O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NC(=O)C3=CC=CC=C3)N=C2)C[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N
LogP: 7.14 at 20℃

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Safety Information

WGK Germany: 3
HS Code: 29349990

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DMT-dA(bz) Phosphoramidite Usage And Synthesis

Physical form

Powder or granules

Color

White to off-white

General Description

DMT-dA(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites. Its key features include:
Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib)).
Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution,for standard base-protected oligonucleotides.
The high coupling efficiency of Proligo′s DNA phosphoramidites leads tohigh-yield and high-quality oligonucleotides.

Uses

N6-Benzoyl-2’-deoxy-5’-O-DMT-cytidine 3’-CE Phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.

DMT-dA(bz) PhosphoramiditeSupplier

Shanghai Peinuo Biotechnology Co., Ltd Gold

Tel: 021-58648778 18217200601
Email: bush@perno.cn

Hongene Biotech Corporation Gold

Tel: 021-64757213
Email: info@hongene.com

Nanjing Youwei Biotechnology Co., Ltd Gold

Tel: 025-86506605 13952030024
Email: 13811988123@139.com

Hefei Huana Biomedical Technology Co.,Ltd Gold

Tel: 17333066501
Email: shengwen.fang@huanaok.com.cn

Tianjin Scaxchem Limited Compnay Gold

Tel: 022-022-25327698 18920479040
Email: sales@cosychem.com

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