2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester Chemical Properties

Density 

1.370±0.06 g/cm3(Predicted)

pka

12.52±0.70(Predicted)

2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester Usage And Synthesis

Uses

VEGFR-2-IN-27 (compound 7a) is a highly potent VEGFR-2 inhibitor with an IC50 value of 14.8 nM. VEGFR-2-IN-27 can be used for researching anticancer[1].

IC 50

VEGFR-2: 14.8 nM (IC₅₀)

References

[1] Hadi SRAE, et al. Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors. Bioorg Chem. 2020 Aug;101:103961. DOI:10.1016/j.bioorg.2020.103961

2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester(2439096-14-5)Related Product Information

• Quinazoline, 4-[(4-bromophenyl)methoxy]-
• 1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-
• VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
• 3-nitro-N-(8-quinolinyl)benzamide
• Pazopanib Impurity 3
• Benzoic acid, 4-[[4-[[2-[2,4-dioxo-5-(phenylmethylene)-3-thiazolidinyl]acetyl]amino]benzoyl]amino]-, ethyl ester
• VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
• 3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)-
• 2,4-PyriMidinediaMine with linker