3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)- Chemical Properties

Boiling point:

625.9±65.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

pka

7.77±0.70(Predicted)

3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)- Usage And Synthesis

Uses

VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase[1].

in vivo

IC 50

VEGFR-2: 0.19 nM (IC₅₀)

References

[1] AbdelHaleem A, et al. Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling. Bioorg Chem. 2020 Oct;103:104222. DOI:10.1016/j.bioorg.2020.104222

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