3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)-

Product Name
3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)-
CAS No.
2411174-53-1
Chemical Name
3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)-
Synonyms
VEGFR-2-IN-23;3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)-
CBNumber
CB912616937
Molecular Formula
C22H15N5O2
Formula Weight
381.39
MOL File
2411174-53-1.mol
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3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)- Property

Boiling point:
625.9±65.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
pka
7.77±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)- Chemical Properties,Usage,Production

Uses

VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase[1].

in vivo

VEGFR-2-IN-23 (5, 10 mg/kg; i.p.) shows inhibits the tumor growth in MCF-7 xenograft tumor models[1].

IC 50

VEGFR-2: 0.19 nM (IC50)

References

[1] AbdelHaleem A, et al. Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling. Bioorg Chem. 2020 Oct;103:104222. DOI:10.1016/j.bioorg.2020.104222

3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)- Suppliers

China 2 United States 1 Global 3
Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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klq@cw-bio.com
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China
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TargetMol Chemicals Inc.
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15002134094
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marketing@targetmol.cn
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China
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29357
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TargetMol Chemicals Inc.
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+17819995354
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marketing@targetmol.com
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United States
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19961
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  • 3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)-
  • VEGFR-2-IN-23
  • 2411174-53-1