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2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester

Product Name
2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester
CAS No.
2439096-14-5
Chemical Name
2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester
Synonyms
VEGFR-2-IN-27;2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester
CBNumber
CB612764022
Molecular Formula
C25H21FN4O4
Formula Weight
460.46
MOL File
2439096-14-5.mol
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2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester Property

Density 
1.370±0.06 g/cm3(Predicted)
pka
12.52±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester Chemical Properties,Usage,Production

Uses

VEGFR-2-IN-27 (compound 7a) is a highly potent VEGFR-2 inhibitor with an IC50 value of 14.8 nM. VEGFR-2-IN-27 can be used for researching anticancer[1].

IC 50

VEGFR-2: 14.8 nM (IC50)

References

[1] Hadi SRAE, et al. Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors. Bioorg Chem. 2020 Aug;101:103961. DOI:10.1016/j.bioorg.2020.103961

2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester Suppliers

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2439096-14-5, 2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl esterRelated Search:

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  • 2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester
  • VEGFR-2-IN-27
  • 2439096-14-5