N-nitroso-3-hydroxypiperidine Chemical Properties

Boiling point:

240.83°C (rough estimate)

Density 

1.2268 (rough estimate)

refractive index 

1.4954 (estimate)

solubility 

soluble in Dichloromethane; Methanol

form 

Oil

color 

Yellow

Safety Information

Toxicity

mma-sat 1 mmol/plate MUREAV 56,131,77

N-nitroso-3-hydroxypiperidine Usage And Synthesis

Uses

(S)-1-Nitrosopiperidin-3-ol is an intermediate in synthesizing Ibrutinib-d4 (I124971), a labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.

Safety Profile

Questionable carcinogen withexperimental tumorigenic data. Human mutation datareported. Many N-nitroso compounds are carcinogens.When heated to decomposition it emits toxic fumes ofNOx.

N-nitroso-3-hydroxypiperidine(55556-85-9)Related Product Information

• 3-Hydroxypiperidine
• N-nitrosomethyl-2-hydroxypropylamine
• N-ETHYL-N-(2-HYDROXYETHYL)NITROSAMINE
• N-NITROSOPIPERIDINE
• N-METHYL-N-(4-HYDROXYBUTYL)NITROSAMINE
• 1-AMINO-PIPERIDIN-3-OL
• N-nitroso-3-hydroxypiperidine