DEBRISOQUIN SULFATE Chemical Properties

Melting point:

278-280°, 284-285° or 266-268° (H2O)

storage temp. 

room temp

solubility 

H₂O: 20 mg/mL with heat

form 

Solid

color 

Pale Yellow

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

26-36

WGK Germany 

3

RTECS 

NW7010000

Toxicity

LD50 in neonate, adult rats (mg/kg): 88 ±18, 1580 ±163 orally (Goldenthal)

MSDS

• Language:English Provider:SigmaAldrich

DEBRISOQUIN SULFATE Usage And Synthesis

Chemical Properties

Crystalline Solid

Originator

Declinax,Roche,UK,1967

Uses

Antihypertensive.

Manufacturing Process

27 g of 1,2,3,4-tetrahydroisoquinoline was added at room temperature to a solution of 28 g of 2-methyl-2-isothiourea sulfate in 80 ml of water. The resulting mixture was kept at room temperature with occasional shaking. After a short period of time, methylmercaptan began to escape, and the mixture warmed up slightly. After then standing for 24 hours, crystals formed. They were filtered off and rinsed with ice cold water. Recrystallization from approximately 100 ml of water yielded 1,2,3,4-tetrahydroisoquinoline-2- carboxamidine sulfate melting at 278°C to 280°C (uncorr.).
Another batch prepared in the same manner melted at 284°C to 285°C due to a minute difference in moisture content.
Both batches prepared above analyzed correctly for (C10H13N3)2·H2SO4.

brand name

Declinax (HoffmannLaRoche).

Therapeutic Function

Antihypertensive

Biochem/physiol Actions

Debrisoquine is an anti-hypertensive agent. It is metabolized by cytochrome P4502D6.

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