1'-Hydroxybufuralol Chemical Properties

Melting point:

41-49°C

Boiling point:

433.0±40.0 °C(Predicted)

Density 

1.139±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)

form 

Solid

pka

13.58±0.20(Predicted)

color 

Off-White to Beige

Stability:

Hygroscopic

1'-Hydroxybufuralol Usage And Synthesis

Description

1’-hydroxy Bufuralol is a metabolite of bufuralol . Bufuralol is metabolized by the cytochrome P450 isoforms 2D1 and 2D2 (CYP2D1/2); therefore, quantification of the bufuralol metabolite, 1’-hydroxy bufuralol, can be used to determine CYP2D1/2 enzyme activity in humans and rats.

Chemical Properties

White to Off-White Solid

Uses

A metabolite of Bufuralol, a β-Adrenergic blocker with peripheral vasodilating activity.

IC 50

CYP2

References

[1] EVANGELOS P DASKALOPOULOS. D?-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D.[J]. Molecular Pharmacology, 2012, 82 4: 668-678. DOI: 10.1124/mol.112.078709
[2] H YAMAZAKI. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.[J]. Molecular Pharmacology, 1994, 46 3: 568-577.

1'-Hydroxybufuralol(57704-16-2)Related Product Information

• 2-(4-Aminophenyl)ethanol
• Propanolol
• Bisoprolol
• Atenolol
• tert-Butanol
• Propranolol hydrochloride
• Ethyl acetate
• Metoprolol
• 2-(METHYLSULFONYL)ETHANOL
• 2,2-Diethoxyethylamine
• Acebutolol
• Tetrahydrofuran
• Monoethanolamine
• Metoprolol tartrate
• 2-Dimethylaminoethanol
• Diethylaminoethanol
• (+/-)-BUFURALOL HYDROCHLORIDE
• 1'-Hydroxybufuralol