4-CHLORO-2-PHENYLQUINAZOLINE Chemical Properties

Melting point:

124-126 °C(lit.)

Boiling point:

383.11°C (rough estimate)

Density 

1.285

refractive index 

1.5749 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

Crystalline Powder

pka

0.67±0.30(Predicted)

color 

Slightly yellow to yellow

InChIKey

OBHKONRNYCDRKM-UHFFFAOYSA-N

CAS DataBase Reference

6484-25-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

WGK Germany 

3

HS Code 

29339980

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

4-CHLORO-2-PHENYLQUINAZOLINE Usage And Synthesis

Chemical Properties

slightly yellow to yellow crystalline powder

Uses

Reactant involved in the synthesis of biologically active molecules including:

• Nitrotriazole amines or nitroimidazole amines for use as antitrypanosomal activity and mammalian cytotoxicity
• Quinazoline-containing piperazinylpyrimidine derivatives with antitumor activity
• Quinazoline substituted cyclopentane as HCV NS3/4A protease inhibitors
• Quinazolines with antibacterial and antitumor activity
• Aurora inhibitor MK-0457

Reactant involved in Suzuki-Miyaura cross-coupling and catalyst-free / base-free water promoted nucleophilic aromatic substitution

Uses

4-Chloro-2-phenylquinazoline can be involved in the synthesis of biologically active molecules including: Nitrotriazole amines or nitroimidazole amines for use as antitrypanosomal activity and mammalian cytotoxicity.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1299, 1946 DOI: 10.1021/ja01211a055

4-CHLORO-2-PHENYLQUINAZOLINE(6484-25-9)Related Product Information

• 4-CHLORO-2-PHENYLQUINAZOLINE
• Oxazoline
• Quinazoline
• 4-CHLORO-2-(2-FLUORO-PHENYL)-QUINAZOLINE
• 2-(4-BROMO-PHENYL)-4-CHLORO-QUINAZOLINE
• QUINAZOLINE, 4-CHLORO-7-FLUORO-2-PHENYL-
• 4-CHLORO-2-(4-METHOXY-PHENYL)-QUINAZOLINE
• 4-CHLORO-2-(4-CHLORO-PHENYL)-QUINAZOLINE
• 4,6-DICHLORO-2-PHENYL-QUINAZOLINE
• 6-BROMO-4-CHLORO-2-PHENYL-QUINAZOLINE
• 4-chloro-2-(2-chlorophenyl)quinazoline
• QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL-
• 4-CHLORO-2-(4-FLUORO-PHENYL)-QUINAZOLINE
• 4,7-DICHLORO-2-PHENYL-QUINAZOLINE
• 6-chloro-4-phenylquinazoline
• 6-BROMO-2-CHLORO-4-PHENYLQUINAZOLINE
• 4-CHLORO-2-(3-CHLORO-PHENYL)-QUINAZOLINE
• AURORA 19333