3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Chemical Properties

Melting point:

185℃

Boiling point:

627.4±65.0 °C(Predicted)

Density 

1.471±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

2-8°C

solubility 

DMSO: ≥15mg/mL

pka

6.29±0.10(Predicted)

form 

Yellow solid

color 

faint yellow to yellow

Safety Information

Hazard Codes 

T

Risk Statements 

25-36

Safety Statements 

26-45

WGK Germany 

3

3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Usage And Synthesis

Uses

Ro 61-8048 is a potent and competitive kynurenine 3-monooxygenase (KMO) inhibitor.

Definition

ChEBI: Ro 61-8048 is a C-nitro compound.

Biological Activity

Potent and competitive kynurenine 3-hydroxylase inhibitor (K i = 4.8 nM, IC 50 = 37 nM). Increases kynurenic acid levels to concentrations that antagonize the glycine site of NMDA receptors. Brain penetrant and exhibits antidystonic, anticonvulsant and neuroprotective activities.

Biochem/physiol Actions

Ro 61-8048 is an inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain.

storage

+4°C

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