RO495
RO495 Basic information
- Product Name:
- RO495
- Synonyms:
-
- RO495
- RO495/RO-495
- RO495 (TYK Tool 1)
- CS-2667
- Benzamide, N-[2-[(2-amino-6-methyl-4-pyrimidinyl)amino]-4-pyridinyl]-2,6-dichloro-
- N-(2-((2-amino-6-methylpyrimidin-4-yl)amino)pyridin-4-yl)-2,6-dichlorobenzamide
- RO495 (CS-2667)
- Janus kinase,Inhibitor,inhibit,RO 495,RO495,JAK,RO-495
- CAS:
- 1258296-60-4
- MF:
- C17H14Cl2N6O
- MW:
- 389.24
- Mol File:
- 1258296-60-4.mol
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RO495 Chemical Properties
- Density
- 1.517±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 78 mg/mL (200.39 mM);Ethanol: Insoluble
- pka
- 10.48±0.70(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- Water Solubility
- Water: Insoluble
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RO495 Usage And Synthesis
Uses
RO495 is a potent inhibitor of non-receptor tyrosine-protein kinase 2 (TYK2 kinase)[1].
References
[1] Tobie D. Lee, et al. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology November 2019, 96 (5) 629-640. DOI:10.1124/mol.119.115964
RO495Supplier
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
SYN|thesis med chem P/L
- Tel
- +86-021-50720296
- service@synkinase.com
LETOPHARM LIMITED
- Tel
- +86-21-5821 5861
- sales@letopharm.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Pharmacodia (Beijing) Co.,Ltd
- Tel
- +86-400-851-9921
- sales@pharmacodia.com
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RO495(1258296-60-4)Related Product Information
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- Bisindoylmaleimide X
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- ROC-325
- RO2959 Hydrochloride
- (S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide