RO495
- Product Name
- RO495
- CAS No.
- 1258296-60-4
- Chemical Name
- RO495
- Synonyms
- RO495;CS-2667;RO495/RO-495;RO495 ，S0384;RO495 (CS-2667);RO495, 10 mM in DMSO;RO495 (TYK Tool 1);Janus kinase,Inhibitor,inhibit,RO 495,RO495,JAK,RO-495;N-[2-[(2-Amino-6-methyl-4-pyrimidinyl)amino]-4-pyridinyl]-2,6-dichlorobenzamide;N-(2-((2-amino-6-methylpyrimidin-4-yl)amino)pyridin-4-yl)-2,6-dichlorobenzamide
- CBNumber
- CB72621147
- Molecular Formula
- C17H14Cl2N6O
- Formula Weight
- 389.24
- MOL File
- 1258296-60-4.mol
RO495 Property
- Density
- 1.517±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 78 mg/mL (200.39 mM);Ethanol: Insoluble
- pka
- 10.48±0.70(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- Water Solubility
- Water: Insoluble
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SYN-1128-M001
- Product name
- RO495
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $211
- Updated
- 2021/12/16
- Product number
- SYN-1128-M010
- Product name
- RO495
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $751
- Updated
- 2021/12/16
- Product number
- SYN1128
- Product name
- RO495
- Packaging
- 50mg
- Price
- $2000
- Updated
- 2021/12/16
- Product number
- SYN-1128-M050
- Product name
- RO495
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $2138
- Updated
- 2021/12/16
- Product number
- DC8528
- Product name
- RO495
- Purity
- >98%
- Packaging
- 1g
- Price
- $2200
- Updated
- 2021/12/16
RO495 Chemical Properties,Usage,Production
Uses
RO495 is a potent inhibitor of non-receptor tyrosine-protein kinase 2 (TYK2 kinase)[1].
References
[1] Tobie D. Lee, et al. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology November 2019, 96 (5) 629-640. DOI:10.1124/mol.119.115964
RO495 Preparation Products And Raw materials
Raw materials
Preparation Products
RO495 Suppliers
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