(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide

Product Name: (S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide
CAS No.: 1191996-10-7
Chemical Name: (S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide
Synonyms: HM-S5552;HM S5552;Sinoliatin;Sinogliatin;Balixafortide;Sinogliatin (HMS5552, RO5305552);HM-S5552; RO-5305552;HM S5552; RO 5305552;(2S)-2-[3-(2-Chlorophenoxy)-5-oxo-2H-pyrrol-1-yl]-N-[1-[(2S)-2,3-dihydroxypropyl]pyrazol-3-yl]-4-methylpentanamide;(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide;(2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2S)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide
CBNumber: CB12743896
Molecular Formula: C22H27ClN4O5
Formula Weight: 462.93
MOL File: 1191996-10-7.mol

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(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide Property

Boiling point:: 761.7±60.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml
DMSO: Slightly soluble: 0.1-1 mg/ml
pka: 12.84±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CCH0033786
Product name: (S)-2-(4-(2-CHLOROPHENOXY)-2-OXO-2,5-DIHYDRO-1H-PYRROL-1-YL)N-(1-((S)-2,3-DIHYDROXYPROPYL)-1H-PYRAZOL-3-YL)-4-METHYLPENTANAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $497.02
Updated: 2021/12/16

DC Chemicals

Product number: DC9690
Product name: Sinogliatin(HMS5552,RO5305552)
Purity: >98%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

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(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide Chemical Properties,Usage,Production

Uses

(S,S)-Sinogliatin ((S,S)-HMS-5552) is the (S,S) -enantiomer of Sinogliatin. Sinogliatin is a glucokinase activator that can be used to study type 2 diabetes[1].

References

[1] Song L, et al. Development of a Physiologically Based Pharmacokinetic Model for Sinogliatin, a First-in-Class Glucokinase Activator, by Integrating Allometric Scaling, In Vitro to In Vivo Exploration and Steady-State Concentration-Mean Residence Time Methods: Mechanistic Understanding of its Pharmacokinetics. Clin Pharmacokinet. 2018 Oct;57(10):1307-1323. DOI:10.1007/s40262-018-0631-z
[2] PING WANG. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus[J]. Journal of Diabetes Research, 2017, 2017 1. DOI: 10.1155/2017/5812607

(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide Suppliers

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1191996-10-7, (S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamideRelated Search:

Ro 3306 Bisindoylmaleimide X RO495 3,4-difluoro-2-(2-fluoro-4-iodophenylaMino)-N-(2-hydroxyethoxy)-5-((3-oxoMorpholino)Methyl)benzaMide 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide ROC-325 RO2959 Hydrochloride

(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide

Sinogliatin

Balixafortide

Sinoliatin

Sinogliatin (HMS5552, RO5305552)

HM S5552

HM-S5552

HM-S5552; RO-5305552;HM S5552; RO 5305552

(2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2S)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide

1H-Pyrrole-1-acetamide, 4-(2-chlorophenoxy)-N-[1-[(2S)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl]-2,5-dihydro-α-(2-methylpropyl)-2-oxo-, (αS)-

(2S)-2-[3-(2-Chlorophenoxy)-5-oxo-2H-pyrrol-1-yl]-N-[1-[(2S)-2,3-dihydroxypropyl]pyrazol-3-yl]-4-methylpentanamide

1191996-10-7