METHYL ACETIMIDATE HYDROCHLORIDE Chemical Properties

Melting point:

105 °C (dec.)(lit.)

storage temp. 

2-8°C

BRN 

3671581

EPA Substance Registry System

Ethanimidic acid, methyl ester, hydrochloride (14777-27-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

AK2950000

F 

10-21

HS Code 

2929900090

MSDS

• Language:English Provider:SigmaAldrich

METHYL ACETIMIDATE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White to yellow powder

Uses

Methyl acetimidate hydrochloride has been used in pre-crystallization chemical modification of lysine residues.

General Description

Methyl acetimidate hydrochloride is an inhibitor of N-methylation of phosphatidylethanolamine. It also prevents the stimulation of purified cardiac sarcolemmal vesicles Ca²⁺-pump activities.

Purification Methods

Crystallise the imidate from methanol by adding dry ether to a ratio of 1:1 and cooling at 0o. Filter off the crystals in a cold room, wash them with methanol/ether (1:2), then dry in a vacuum. [Hunter & Ludwig J Am Chem Soc 84 3491 1962.] The free base has b 90-91o/765mm, d 0.867, n 1.403. [Hunter & Ludwig Methods Enzymol 25 585 1973, Beilstein 2 IV 181.]

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