tasquinimod Chemical Properties

Boiling point:

501.5±50.0 °C(Predicted)

Density 

1.427±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

insoluble in H2O; ≥20.32 mg/mL in DMSO; ≥4.75 mg/mL in EtOH with gentle warming and ultrasonic

form 

solid

pka

4.50±1.00(Predicted)

color 

White to light yellow

tasquinimod Usage And Synthesis

Description

Tasquinimod is an orally-active quinoline-3-carboxamide derived from roquinimex, an immunomodulatory quinolone with applications in some cancers and autoimmune diseases. Tasquinimod inhibits tumor angiogenesis and supplements radiation or chemotherapy in animal models of prostate cancer. While its precise mechanism of action remains unclear, tasquinimod has been reported to alter signaling through S100A9, thrombospondin-1, HIF-1α, androgen receptor, VEGF, and HDAC3/4.

Uses

Tasquinimod is an orally active antiangiogenic agent which may inhibit HDAC4 signalling. This affects cancer cell survival thus making this compound and anti-cancer agent.

target

tumor microenvironment

storage

Store at -20°C

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