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2'-Deoxy-5'-O-DMT-2'-fluorouridine

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2'-Deoxy-5'-O-DMT-2'-fluorouridine Basic information

Product Name:
2'-Deoxy-5'-O-DMT-2'-fluorouridine
Synonyms:
  • 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE
  • 2'-Deoxy-5'-O-DMT-2'-fluoro-D-uridine
  • 2'-Deoxy-5'-O-DMT-2'-fluorouridine
  • 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine
  • 5'-O-(4,4'-DiMethoxytrityl)-2'-fluoro-2'-deoxyuridine
  • 1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
  • 5'-O-DMT-2'-Fluoro-2'-deoxyuridine
  • 1-((2R,3R,4R,5R)
CAS:
146954-74-7
MF:
C30H29FN2O7
MW:
548.56
EINECS:
2017-001-1
Product Categories:
  • Modified(deoxy)nucleoside
Mol File:
146954-74-7.mol
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2'-Deoxy-5'-O-DMT-2'-fluorouridine Chemical Properties

Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
9.39±0.10(Predicted)
form 
Powder
color 
White to Pale Yellow
InChIKey
CSSFZSSZXOCCJB-MNBKXICWNA-N
SMILES
N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2=CC=C(C=C2)OC)C2=CC=C(C=C2)OC)[C@@H](O)[C@H]1F |&1:8,10,36,38,r|
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Safety Information

HS Code 
2934999090
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2'-Deoxy-5'-O-DMT-2'-fluorouridine Usage And Synthesis

Definition

2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity.

Biological Activity

2'-Deoxy-5'-O-DMT-2'-fluorouridine (compound 15h) has 100% inhibition against YFV at 20 mM. 2'-Deoxy-5'-O-DMT-2'-fluorouridine proves to be noncytotoxic at concentrations up to 20 mM.

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