2'-Fluoro-2'-deoxyuridine Chemical Properties

Melting point:

147.0 to 153.0 °C

Density 

1.63±0.1 g/cm3(Predicted)

refractive index 

53 ° (C=0.3, H2O)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Soluble in methanol.

form 

Powder

pka

9.39±0.10(Predicted)

color 

White to Off-white

InChI

InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1

InChIKey

UIYWFOZZIZEEKJ-XVFCMESISA-N

SMILES

OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O

CAS DataBase Reference

784-71-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-40

Safety Statements 

22-36/37/39

HS Code 

29389090

2'-Fluoro-2'-deoxyuridine Usage And Synthesis

Description

2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.

Chemical Properties

White to almost white crystalline powder

Uses

2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

Uses

A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

2'-Fluoro-2'-deoxyuridine(784-71-4)Related Product Information

• Trifluridine
• 2'-Deoxyuridine
• Doxifluridine
• 2'-DEOXY-2'-FLUOROTHYMIDINE
• 5-Fluoro-2'-deoxyuridine 98%,(+)-5-FLUORO-2'-DEOXYURIDINE,5-FLUORO-2'-DEOXYURIDINE,5-FLUORO-2-DEOXYURIDINE,beta-5-fluoro-2’-deoxyuridin
• uridine diphosphate glucose {= UDP-glucose}
• BrdU (Bromodeoxyuridine)
• Fluorine
• DMT-2′Fluoro-dU Phosphoramidite
• Uridine
• 2',2'-DIFLUORO-2'-DEOXYURIDINE
• 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE
• 2'-FLUORODEOXYURIDINE-5,6-D2
• 2'-FLUORO-2'DEOXYURIDINE, [5'-3H]
• 2',2'-DIFLUORO-2'-DEOXYURIDINE 13C, 15N2
• 3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE
• 5-FLUORO 2'-DEOXYURIDINE, [6-3H]-,5'-FLUORO-2'DEOXYURIDINE, [6-3H]
• 3',5'-DI-O-ACETYL-5-FLUORO-2'-DEOXYURIDINE